两个丁二肟有机锡配合物的合成、结构及抗癌活性

Jingjing Qing; Fan He; Zhihui Liu; Shuaipeng Hou; Ya Liu; Yifan Jiang; Mengting Tan; Lifang He; Fuxing Zhang; Xiaoming Zhu

doi:10.11862/CJIC.20240003

两个丁二肟有机锡配合物的合成、结构及抗癌活性

Translated title of the contribution: Synthesis, structure, and anticancer activity of two complexes of dimethylglyoxime organotin

Jingjing Qing, Fan He, Zhihui Liu, Shuaipeng Hou, Ya Liu, Yifan Jiang, Mengting Tan, Lifang He, Fuxing Zhang, Xiaoming Zhu

Hengyang Normal University

Research output: Contribution to journal › Article › peer-review

Abstract

Two dimethylglyoxime organotin compounds, bis(tri(2‑methyl‑2‑phenylpropyl)tin) dimethylglyoxime com‑ plex (C₆H₅C(CH₃)₂CH₂)₃Sn(ON= C(CH₃)C(CH₃) = NO)Sn(CH₂C(CH₃)₂C₆H₅)₃ (1) and di(benzyl)tin oxide, chlorine, butanedione oxime multinuclear complex [μ₃‑O‑((C₆H₅CH₂)₂Sn)₂(ON= C(CH₃)C(CH₃)= NOH)(O)Cl]₂ (2), were syn‑ thesized. The compounds were characterized by elemental analysis, IR spectroscopy, NMR (¹H, ¹³C, and ¹¹⁹Sn), ther‑ mogravimetric analysis, and single‑crystal X‑ray diffraction, and quantum chemical ab initio calculation was per‑ formed for their structure and in vitro anticancer activity were studied for the compounds. The results showed that complex 1 is a central symmetric molecule with double tin nuclei bridged by the ligand dimethylglyoxime, and the tin atoms are distorted tetrahedral configurations with four coordination. Complex 2 is a central symmetric polycy‑ clic polymerization structure of tetra‑tin nuclei bridged by oxygen atoms and dimethylglyoxime, and the tin atoms are five‑coordinated distorted triangular bipyramidal configuration and six‑coordinated distorted octahedral configu‑ ration, respectively. In addition, the complexes have stronger inhibitory activity on human liver cancer cells(HUH7), human lung cancer cells (A549), human epidermal cancer cells (A431), human colon cancer cells (HCT‑116), and breast cancer cells (MDA‑MB‑231). CCDC: 2234708, 1; 2234707, 2.

Translated title of the contribution	Synthesis, structure, and anticancer activity of two complexes of dimethylglyoxime organotin
Original language	Chinese (Traditional)
Pages (from-to)	1301-1308
Number of pages	8
Journal	Chinese Journal of Inorganic Chemistry
Volume	40
Issue number	7
DOIs	https://doi.org/10.11862/CJIC.20240003
State	Published - Jul 2024
Externally published	Yes

Scopus Subject Areas

Inorganic Chemistry

Keywords

ab initio calculation
bis(tri(2‑methyl‑2‑phenylpropyl)tin) butanedione oxime complex
di(benzyl)tin oxide chlorine butanedione oxime multinuclear complex
in vitro antitumor activity
quantum chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11862/CJIC.20240003

Cite this

@article{f5adda4f7a7844c8bd8fb0b31b152c82,

title = "两个丁二肟有机锡配合物的合成、结构及抗癌活性",

abstract = "Two dimethylglyoxime organotin compounds, bis(tri(2‑methyl‑2‑phenylpropyl)tin) dimethylglyoxime com‑ plex (C6H5C(CH3)2CH2)3Sn(ON= C(CH3)C(CH3) = NO)Sn(CH2C(CH3)2C6H5)3 (1) and di(benzyl)tin oxide, chlorine, butanedione oxime multinuclear complex [μ3‑O‑((C6H5CH2)2Sn)2(ON= C(CH3)C(CH3)= NOH)(O)Cl]2 (2), were syn‑ thesized. The compounds were characterized by elemental analysis, IR spectroscopy, NMR (1H, 13C, and 119Sn), ther‑ mogravimetric analysis, and single‑crystal X‑ray diffraction, and quantum chemical ab initio calculation was per‑ formed for their structure and in vitro anticancer activity were studied for the compounds. The results showed that complex 1 is a central symmetric molecule with double tin nuclei bridged by the ligand dimethylglyoxime, and the tin atoms are distorted tetrahedral configurations with four coordination. Complex 2 is a central symmetric polycy‑ clic polymerization structure of tetra‑tin nuclei bridged by oxygen atoms and dimethylglyoxime, and the tin atoms are five‑coordinated distorted triangular bipyramidal configuration and six‑coordinated distorted octahedral configu‑ ration, respectively. In addition, the complexes have stronger inhibitory activity on human liver cancer cells(HUH7), human lung cancer cells (A549), human epidermal cancer cells (A431), human colon cancer cells (HCT‑116), and breast cancer cells (MDA‑MB‑231). CCDC: 2234708, 1; 2234707, 2.",

keywords = "ab initio calculation, bis(tri(2‑methyl‑2‑phenylpropyl)tin) butanedione oxime complex, di(benzyl)tin oxide chlorine butanedione oxime multinuclear complex, in vitro antitumor activity, quantum chemistry",

author = "Jingjing Qing and Fan He and Zhihui Liu and Shuaipeng Hou and Ya Liu and Yifan Jiang and Mengting Tan and Lifang He and Fuxing Zhang and Xiaoming Zhu",

year = "2024",

month = jul,

doi = "10.11862/CJIC.20240003",

language = "Chinese (Traditional)",

volume = "40",

pages = "1301--1308",

journal = "Chinese Journal of Inorganic Chemistry",

issn = "1001-4861",

publisher = "Chinese Chemical Society",

number = "7",

}

TY - JOUR

T1 - 两个丁二肟有机锡配合物的合成、结构及抗癌活性

AU - Qing, Jingjing

AU - He, Fan

AU - Liu, Zhihui

AU - Hou, Shuaipeng

AU - Liu, Ya

AU - Jiang, Yifan

AU - Tan, Mengting

AU - He, Lifang

AU - Zhang, Fuxing

AU - Zhu, Xiaoming

PY - 2024/7

Y1 - 2024/7

N2 - Two dimethylglyoxime organotin compounds, bis(tri(2‑methyl‑2‑phenylpropyl)tin) dimethylglyoxime com‑ plex (C6H5C(CH3)2CH2)3Sn(ON= C(CH3)C(CH3) = NO)Sn(CH2C(CH3)2C6H5)3 (1) and di(benzyl)tin oxide, chlorine, butanedione oxime multinuclear complex [μ3‑O‑((C6H5CH2)2Sn)2(ON= C(CH3)C(CH3)= NOH)(O)Cl]2 (2), were syn‑ thesized. The compounds were characterized by elemental analysis, IR spectroscopy, NMR (1H, 13C, and 119Sn), ther‑ mogravimetric analysis, and single‑crystal X‑ray diffraction, and quantum chemical ab initio calculation was per‑ formed for their structure and in vitro anticancer activity were studied for the compounds. The results showed that complex 1 is a central symmetric molecule with double tin nuclei bridged by the ligand dimethylglyoxime, and the tin atoms are distorted tetrahedral configurations with four coordination. Complex 2 is a central symmetric polycy‑ clic polymerization structure of tetra‑tin nuclei bridged by oxygen atoms and dimethylglyoxime, and the tin atoms are five‑coordinated distorted triangular bipyramidal configuration and six‑coordinated distorted octahedral configu‑ ration, respectively. In addition, the complexes have stronger inhibitory activity on human liver cancer cells(HUH7), human lung cancer cells (A549), human epidermal cancer cells (A431), human colon cancer cells (HCT‑116), and breast cancer cells (MDA‑MB‑231). CCDC: 2234708, 1; 2234707, 2.

AB - Two dimethylglyoxime organotin compounds, bis(tri(2‑methyl‑2‑phenylpropyl)tin) dimethylglyoxime com‑ plex (C6H5C(CH3)2CH2)3Sn(ON= C(CH3)C(CH3) = NO)Sn(CH2C(CH3)2C6H5)3 (1) and di(benzyl)tin oxide, chlorine, butanedione oxime multinuclear complex [μ3‑O‑((C6H5CH2)2Sn)2(ON= C(CH3)C(CH3)= NOH)(O)Cl]2 (2), were syn‑ thesized. The compounds were characterized by elemental analysis, IR spectroscopy, NMR (1H, 13C, and 119Sn), ther‑ mogravimetric analysis, and single‑crystal X‑ray diffraction, and quantum chemical ab initio calculation was per‑ formed for their structure and in vitro anticancer activity were studied for the compounds. The results showed that complex 1 is a central symmetric molecule with double tin nuclei bridged by the ligand dimethylglyoxime, and the tin atoms are distorted tetrahedral configurations with four coordination. Complex 2 is a central symmetric polycy‑ clic polymerization structure of tetra‑tin nuclei bridged by oxygen atoms and dimethylglyoxime, and the tin atoms are five‑coordinated distorted triangular bipyramidal configuration and six‑coordinated distorted octahedral configu‑ ration, respectively. In addition, the complexes have stronger inhibitory activity on human liver cancer cells(HUH7), human lung cancer cells (A549), human epidermal cancer cells (A431), human colon cancer cells (HCT‑116), and breast cancer cells (MDA‑MB‑231). CCDC: 2234708, 1; 2234707, 2.

KW - ab initio calculation

KW - bis(tri(2‑methyl‑2‑phenylpropyl)tin) butanedione oxime complex

KW - di(benzyl)tin oxide chlorine butanedione oxime multinuclear complex

KW - in vitro antitumor activity

KW - quantum chemistry

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U2 - 10.11862/CJIC.20240003

DO - 10.11862/CJIC.20240003

M3 - Article

AN - SCOPUS:85198988394

SN - 1001-4861

VL - 40

SP - 1301

EP - 1308

JO - Chinese Journal of Inorganic Chemistry

JF - Chinese Journal of Inorganic Chemistry

IS - 7

ER -

两个丁二肟有机锡配合物的合成、结构及抗癌活性

Abstract

Scopus Subject Areas

Keywords

UN SDGs

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