1.15 Å Resolution Structure of the Proteasome-Assembly Chaperone Nas2 PDZ Domain

Chingakham R. Singh, Scott Lovell, Nurjahan Mehzabeen, Wasimul Q. Chowdhury, Kevin P. Battaile, Jeroen Roelofs

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6 Scopus citations
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Abstract

<div class="line" id="line-10"> The 26S proteasome is a 2.5 MDa protease dedicated to the degradation of ubiquitinated proteins in eukaryotes. The assembly of this complex containing 66 polypeptides is assisted by at least nine proteasome-specific chaperones. One of these, Nas2, binds to the proteasomal AAA-ATPase subunit Rpt5. The PDZ domain of Nas2 binds to the C-terminal tail of Rpt5; however, it does not require the C-terminus of Rpt5 for binding. Here, the 1.15 A&ring; resolution structure of the PDZ domain of Nas2 is reported. This structure will provide a basis for further insights regarding the structure and function of Nas2 in proteasome assembly</div>
Original languageAmerican English
JournalActa Crystallographica Section F: Structural Biology Communications
Volume70
DOIs
StatePublished - Mar 25 2014

DC Disciplines

  • Biology

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