Abstract
<div class="line" id="line-10"> The 26S proteasome is a 2.5 MDa protease dedicated to the degradation of ubiquitinated proteins in eukaryotes. The assembly of this complex containing 66 polypeptides is assisted by at least nine proteasome-specific chaperones. One of these, Nas2, binds to the proteasomal AAA-ATPase subunit Rpt5. The PDZ domain of Nas2 binds to the C-terminal tail of Rpt5; however, it does not require the C-terminus of Rpt5 for binding. Here, the 1.15 A˚ resolution structure of the PDZ domain of Nas2 is reported. This structure will provide a basis for further insights regarding the structure and function of Nas2 in proteasome assembly</div>
Original language | American English |
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Journal | Acta Crystallographica Section F: Structural Biology Communications |
Volume | 70 |
DOIs | |
State | Published - Mar 25 2014 |
DC Disciplines
- Biology