@article{fbf1652292d34c58afc7eb08400ac1d8,
title = "A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: Design, synthesis, and in vitro and in vivo evaluation",
abstract = "(Chemical Equation Presented) Protein arginine methyltransferases (PRMTs) catalyze the post-translational methylation of arginine residues. PRMT1 is the predominant mammalian isozyme and is responsible for generating the majority of the asymmetrically dimethylated arginine found in vivo. Herein, we describe the most potent PRMT1 inhibitor, C21, described to date.",
keywords = "Cl-amidine, Enzymes, Inhibitors, Protein arginine methyltransferase, Transcription",
author = "Obiamaka Obianyo and Causey, \{Corey P.\} and Osborne, \{Tanesha C.\} and Jones, \{Justin E.\} and Young-Ho Lee and Stallcup, \{Michael R.\} and Thompson, \{Paul R.\}",
note = "Obiamaka Obianyo, Corey P. Causey, Tanesha C. Osborne, Justin E. Jones, Young-Ho Lee, Michael R. Stallcup, and Paul R. Thompson. {"}A Chloroacetamidine-based Inactivator of Protein Arginine Methyltransferase 1: Design, Synthesis, and in Vitro and in Vivo Evaluation{"} ChemBioChem 11.9 (2010): 1219-1223. doi:10.1002/cbic.201000209 source:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060404/ Available at: http://works.bepress.com/tanesha\_osborne/3",
year = "2010",
month = jun,
day = "14",
doi = "10.1002/cbic.201000209",
language = "English",
volume = "11",
pages = "1219--1223",
journal = "ChemBioChem",
issn = "1439-4227",
publisher = "John Wiley and Sons Inc.",
number = "9",
}
