TY - JOUR
T1 - A deterministic compartmental model for investigating the impact of escapees on the transmission dynamics of COVID-19
AU - Mushanyu, Josiah
AU - Chukwu, Chidozie Williams
AU - Madubueze, Chinwendu Emilian
AU - Chazuka, Zviiteyi
AU - Ogbogbo, Chisara Peace
N1 - Publisher Copyright:
© 2023
PY - 2023/12
Y1 - 2023/12
N2 - The recent outbreak of the novel coronavirus (COVID-19) pandemic has devastated many parts of the globe. Non-pharmaceutical interventions are the widely available measures to combat and control the COVID-19 pandemic. There is great concern over the rampant unaccounted cases of individuals skipping the border during this critical period in time. We develop a deterministic compartmental model to investigate the impact of escapees (individuals who evade mandatory quarantine) on the transmission dynamics of COVID-19. A suitable Lyapunov function has shown that the disease-free equilibrium is globally asymptotically stable, provided R0<1. We performed a global sensitivity analysis using the Latin-hyper cube sampling method and partial rank correlation coefficients to determine the most influential model parameters on the short and long-term dynamics of the pandemic to minimize uncertainties associated with our variables and parameters. Results confirm a positive correlation between the number of escapees and the reported COVID-19 cases. It is shown that escapees are primarily responsible for the rapid increase in local transmissions. Also, the results from sensitivity analysis show that an increase in governmental role actions and a reduction in the illegal immigration rate will help to control and contain the disease spread.
AB - The recent outbreak of the novel coronavirus (COVID-19) pandemic has devastated many parts of the globe. Non-pharmaceutical interventions are the widely available measures to combat and control the COVID-19 pandemic. There is great concern over the rampant unaccounted cases of individuals skipping the border during this critical period in time. We develop a deterministic compartmental model to investigate the impact of escapees (individuals who evade mandatory quarantine) on the transmission dynamics of COVID-19. A suitable Lyapunov function has shown that the disease-free equilibrium is globally asymptotically stable, provided R0<1. We performed a global sensitivity analysis using the Latin-hyper cube sampling method and partial rank correlation coefficients to determine the most influential model parameters on the short and long-term dynamics of the pandemic to minimize uncertainties associated with our variables and parameters. Results confirm a positive correlation between the number of escapees and the reported COVID-19 cases. It is shown that escapees are primarily responsible for the rapid increase in local transmissions. Also, the results from sensitivity analysis show that an increase in governmental role actions and a reduction in the illegal immigration rate will help to control and contain the disease spread.
KW - Correlation
KW - COVID-19
KW - Deterministic model
KW - Escapees
KW - Numerical simulations
KW - Quarantine
UR - https://www.scopus.com/pages/publications/85176226091
UR - https://www.sciencedirect.com/science/article/pii/S2772442523001429?via%3Dihub
U2 - 10.1016/j.health.2023.100275
DO - 10.1016/j.health.2023.100275
M3 - Article
AN - SCOPUS:85176226091
SN - 2772-4425
VL - 4
JO - Healthcare Analytics
JF - Healthcare Analytics
M1 - 100275
ER -