A medical follow-up of the health effects of long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Gregory Evans; Karen B. Webb; Alan P. Knutsen; Standford T. Roodman; Daryl W. Roberts; John R. Bagby; Woodrow A. Garrett; John S. Andrew

doi:10.1080/00039896.1988.10545949

A medical follow-up of the health effects of long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Gregory Evans, Karen B. Webb, Alan P. Knutsen, Standford T. Roodman, Daryl W. Roberts, John R. Bagby, Woodrow A. Garrett, John S. Andrew

Health Policy & Community Health

St. Louis University School of Medicine

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The human health effects of long-term exposure to low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have not been well established. The results of a prior study showed that persons exposed to TCDD had depressed cell-mediated immunity, and 18 of 51 persons had anergy or relative anergy on skin testing. This paper presents the results of a medical follow-up on participants who were reported to be anergic or relatively anergic in the earlier study. None of the participants in the follow-up study was anergic, and only one exposed and one unexposed participant were relatively anergic. Several technical and biological possibilities for the difference in results of the two studies are presented. The possibility that recovery from the effects of TCDD exposure caused the differing results is the least plausible explanation for the changes in the skin test results.

Original language	English
Pages (from-to)	273-278
Number of pages	6
Journal	Archives of Environmental Health
Volume	43
Issue number	4
DOIs	https://doi.org/10.1080/00039896.1988.10545949
State	Published - 1988

Scopus Subject Areas

Environmental Chemistry
General Environmental Science
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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title = "A medical follow-up of the health effects of long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin",

abstract = " The human health effects of long-term exposure to low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have not been well established. The results of a prior study showed that persons exposed to TCDD had depressed cell-mediated immunity, and 18 of 51 persons had anergy or relative anergy on skin testing. This paper presents the results of a medical follow-up on participants who were reported to be anergic or relatively anergic in the earlier study. None of the participants in the follow-up study was anergic, and only one exposed and one unexposed participant were relatively anergic. Several technical and biological possibilities for the difference in results of the two studies are presented. The possibility that recovery from the effects of TCDD exposure caused the differing results is the least plausible explanation for the changes in the skin test results.",

author = "Gregory Evans and Webb, \{Karen B.\} and Knutsen, \{Alan P.\} and Roodman, \{Standford T.\} and Roberts, \{Daryl W.\} and Bagby, \{John R.\} and Garrett, \{Woodrow A.\} and Andrew, \{John S.\}",

note = "The human health effects of long-term exposure to low levels of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) have not been well established. The results of a prior study showed that persons exposed to TCDD had depressed cell-mediated immunity, and 18 of 51 persons had anergy or relative anergy on skin testing.",

year = "1988",

doi = "10.1080/00039896.1988.10545949",

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T1 - A medical follow-up of the health effects of long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

AU - Evans, Gregory

AU - Webb, Karen B.

AU - Knutsen, Alan P.

AU - Roodman, Standford T.

AU - Roberts, Daryl W.

AU - Bagby, John R.

AU - Garrett, Woodrow A.

AU - Andrew, John S.

N1 - The human health effects of long-term exposure to low levels of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) have not been well established. The results of a prior study showed that persons exposed to TCDD had depressed cell-mediated immunity, and 18 of 51 persons had anergy or relative anergy on skin testing.

PY - 1988

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N2 - The human health effects of long-term exposure to low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have not been well established. The results of a prior study showed that persons exposed to TCDD had depressed cell-mediated immunity, and 18 of 51 persons had anergy or relative anergy on skin testing. This paper presents the results of a medical follow-up on participants who were reported to be anergic or relatively anergic in the earlier study. None of the participants in the follow-up study was anergic, and only one exposed and one unexposed participant were relatively anergic. Several technical and biological possibilities for the difference in results of the two studies are presented. The possibility that recovery from the effects of TCDD exposure caused the differing results is the least plausible explanation for the changes in the skin test results.

AB - The human health effects of long-term exposure to low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have not been well established. The results of a prior study showed that persons exposed to TCDD had depressed cell-mediated immunity, and 18 of 51 persons had anergy or relative anergy on skin testing. This paper presents the results of a medical follow-up on participants who were reported to be anergic or relatively anergic in the earlier study. None of the participants in the follow-up study was anergic, and only one exposed and one unexposed participant were relatively anergic. Several technical and biological possibilities for the difference in results of the two studies are presented. The possibility that recovery from the effects of TCDD exposure caused the differing results is the least plausible explanation for the changes in the skin test results.

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DO - 10.1080/00039896.1988.10545949

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VL - 43

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JO - Archives of Environmental Health

JF - Archives of Environmental Health

IS - 4

ER -

A medical follow-up of the health effects of long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Abstract

Scopus Subject Areas

UN SDGs

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