TY - JOUR
T1 - A pathogenic role for splenic B1 cells in SIV disease progression in rhesus macaques
AU - Enyindah-Asonye, Gospel
AU - Nwankwo, Anthony
AU - Hogge, Christopher
AU - Rahman, Mohammad Arif
AU - Hait, Sabrina Helmold
AU - Hunegnaw, Ruth
AU - Ko, Eun Ju
AU - Hoang, Tanya
AU - Venzon, David J.
AU - Robert-Guroff, Marjorie
N1 - Publisher Copyright:
Copyright © 2019 Enyindah-Asonye, Nwankwo, Hogge, Rahman, Helmold Hait, Hunegnaw, Ko, Hoang, Venzon and Robert-Guroff. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
PY - 2019
Y1 - 2019
N2 - B1 cells spontaneously produce protective natural antibodies which provide the first line of defense against a variety of pathogens. Although these natural antibodies share similar autoreactive features with several HIV-1 broadly neutralizing antibodies, the role of B1 cells in HIV/SIV disease progression is unknown. We report the presence of human-like B1 cells in rhesus macaques. During chronic SIV infection, we found that the frequency of splenic CD11b+ B1 cells positively correlated with plasma SIV viral load and exhausted T cells. Mechanistically, we discovered that splenic CD11b+ B1 cells express PD-L2 and IL-10, and were able to induce PD-1 upregulation on CD4+ T cells in vitro. These findings suggest that splenic CD11b+ B1 cells may contribute to the regulation of SIV plasma viral load by enhancing T cell exhaustion. Therefore, understanding the mechanisms that govern their function in rhesus macaques may lead to novel therapeutic strategies for impeding HIV/SIV disease progression.
AB - B1 cells spontaneously produce protective natural antibodies which provide the first line of defense against a variety of pathogens. Although these natural antibodies share similar autoreactive features with several HIV-1 broadly neutralizing antibodies, the role of B1 cells in HIV/SIV disease progression is unknown. We report the presence of human-like B1 cells in rhesus macaques. During chronic SIV infection, we found that the frequency of splenic CD11b+ B1 cells positively correlated with plasma SIV viral load and exhausted T cells. Mechanistically, we discovered that splenic CD11b+ B1 cells express PD-L2 and IL-10, and were able to induce PD-1 upregulation on CD4+ T cells in vitro. These findings suggest that splenic CD11b+ B1 cells may contribute to the regulation of SIV plasma viral load by enhancing T cell exhaustion. Therefore, understanding the mechanisms that govern their function in rhesus macaques may lead to novel therapeutic strategies for impeding HIV/SIV disease progression.
KW - B1 cells
KW - Exhaustion
KW - Rhesus macaque
KW - Simian immunodeficiency virus
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=85064223967&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2019.00511
DO - 10.3389/fimmu.2019.00511
M3 - Article
C2 - 30941141
AN - SCOPUS:85064223967
SN - 1664-3224
VL - 10
JO - Frontiers in Immunology
JF - Frontiers in Immunology
IS - MAR
M1 - 511
ER -
