Abstract
A novel, mild synthesis of aryl-3,3,3-trifluoropropenes by Wittig olefination of benzylphosphonium ylides with in-situ generated trifluoroacetaldehyde is described. The in-situ formed trifluoroacetaldehyde efficiently traps the Wittig ylides and yields trifluoromethyl alkenes without the troublesome handling. The scope of the reaction was tested in reaction of trifluoroacetaldehyde with a wide variety of benzylphosphonium ylides. The α-trifluoromethyl alkenes were isolated in good to excellent yields in a convenient one step process.
| Original language | American English |
|---|---|
| Journal | The Journal of Organic Chemistry |
| Volume | 6 |
| State | Published - 2009 |
Keywords
- Trifluoroacetaldehyde ethyl hemiacetal
- aryl-α-trifluoromethyl-alkenes
- fluoral
- witting coupling
DC Disciplines
- Chemistry