Battling against host phagocytes: The wherefore of the RTX family of toxins?

R. A. Welch; M. E. Bauer; A. D. Kent; J. A. Leeds; M. Moayeri; L. B. Regassa; D. L. Swenson

Battling against host phagocytes: The wherefore of the RTX family of toxins?

R. A. Welch, M. E. Bauer, A. D. Kent, J. A. Leeds, M. Moayeri, L. B. Regassa, D. L. Swenson

Biology

University of Wisconsin–Madison

Research output: Contribution to journal › Short survey › peer-review

58 Scopus citations

Abstract

The RTX family of bacterial exotoxins is a group of related cytolytic proteins produced by a wide variety of gram-negative human and animal pathogens. While diverse in their associated diseases and in their target cell specificities, there remain several themes common to RTX toxins, including genetic organization, structural and functional features, and effects on target cells. In this review, we summarize and discuss the genetics, regulation, epidemiology, structure/function relationships, and in vivo and in vitro activities of the best characterized RTX toxins, and speculate on their roles in pathogenesis and their use in immunotherapy.

Original language	English
Pages (from-to)	254-272
Number of pages	19
Journal	Infectious Agents and Disease
Volume	4
Issue number	4
State	Published - 1995

Keywords

Hemolysin
Leukotoxin
RTX exotoxin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{91dbdfa6273f4ad6a99300afab99b826,

title = "Battling against host phagocytes: The wherefore of the RTX family of toxins?",

abstract = "The RTX family of bacterial exotoxins is a group of related cytolytic proteins produced by a wide variety of gram-negative human and animal pathogens. While diverse in their associated diseases and in their target cell specificities, there remain several themes common to RTX toxins, including genetic organization, structural and functional features, and effects on target cells. In this review, we summarize and discuss the genetics, regulation, epidemiology, structure/function relationships, and in vivo and in vitro activities of the best characterized RTX toxins, and speculate on their roles in pathogenesis and their use in immunotherapy.",

keywords = "Hemolysin, Leukotoxin, RTX exotoxin",

author = "Welch, {R. A.} and Bauer, {M. E.} and Kent, {A. D.} and Leeds, {J. A.} and M. Moayeri and Regassa, {L. B.} and Swenson, {D. L.}",

year = "1995",

language = "English",

volume = "4",

pages = "254--272",

journal = "Infectious Agents and Disease",

issn = "1056-2044",

publisher = "Raven Press",

number = "4",

}

TY - JOUR

T1 - Battling against host phagocytes

T2 - The wherefore of the RTX family of toxins?

AU - Welch, R. A.

AU - Bauer, M. E.

AU - Kent, A. D.

AU - Leeds, J. A.

AU - Moayeri, M.

AU - Regassa, L. B.

AU - Swenson, D. L.

PY - 1995

Y1 - 1995

N2 - The RTX family of bacterial exotoxins is a group of related cytolytic proteins produced by a wide variety of gram-negative human and animal pathogens. While diverse in their associated diseases and in their target cell specificities, there remain several themes common to RTX toxins, including genetic organization, structural and functional features, and effects on target cells. In this review, we summarize and discuss the genetics, regulation, epidemiology, structure/function relationships, and in vivo and in vitro activities of the best characterized RTX toxins, and speculate on their roles in pathogenesis and their use in immunotherapy.

AB - The RTX family of bacterial exotoxins is a group of related cytolytic proteins produced by a wide variety of gram-negative human and animal pathogens. While diverse in their associated diseases and in their target cell specificities, there remain several themes common to RTX toxins, including genetic organization, structural and functional features, and effects on target cells. In this review, we summarize and discuss the genetics, regulation, epidemiology, structure/function relationships, and in vivo and in vitro activities of the best characterized RTX toxins, and speculate on their roles in pathogenesis and their use in immunotherapy.

KW - Hemolysin

KW - Leukotoxin

KW - RTX exotoxin

UR - http://www.scopus.com/inward/record.url?scp=0029561139&partnerID=8YFLogxK

M3 - Short survey

C2 - 8665089

AN - SCOPUS:0029561139

SN - 1056-2044

VL - 4

SP - 254

EP - 272

JO - Infectious Agents and Disease

JF - Infectious Agents and Disease

IS - 4

ER -

Battling against host phagocytes: The wherefore of the RTX family of toxins?

Abstract

Keywords

UN SDGs

Other files and links

Fingerprint

Cite this