Chemical variability within the marine sponge Aplysina fulva

Cecília V. Nuñez, Erika V.R. de Almeida, Ana Claudia Granato, Suzi O. Marques, Kelly O. Santos, Fabio R. Pereira, Mario L. Macedo, Antonio G. Ferreira, Eduardo Hajdu, Ulisses S. Pinheiro, Guilherme Muricy, Solange Peixinho, Christopher J. Freeman, Daniel F. Gleason, Roberto G.S. Berlinck

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Dibromotyrosine-derived metabolites are of common occurrence within marine sponges belonging to the order Verongida. However, previous chemical analysis of crude extracts obtained from samples of the verongid sponge Aplysina fulva collected in Brazil did not provide any dibromotyrosine-derived compounds. In this investigation, five samples of A. fulva from five different locations along the Brazilian coastline and one sample from a temperate reef in the South Atlantic Bight (SAB) (Georgia, USA) were investigated for the presence of bromotyrosine-derived compounds. All six samples collected yielded dibromotyrosine-derived compounds, including a new derivative, named aplysinafulvin, which has been identified by analysis of spectroscopic data. These results confirm previous assumptions that dibromotyrosine-derived metabolites can be considered as chemotaxonomic markers of verongid sponges. The isolation of aplysinafulvin provides additional support for a biogenetic pathway involving an arene oxide intermediate in the biosynthesis of Verongida metabolites. It cannot yet be established if the chemical variability observed among the six samples of A. fulva collected in Brazil and the SAB is the result of different environmental factors, distinct chemical extraction and isolation protocols, or a consequence of hidden genetic diversity within the postulated morphological plasticity of this species.

Original languageEnglish
Pages (from-to)283-296
Number of pages14
JournalBiochemical Systematics and Ecology
Volume36
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • Aplysina fulva
  • Chemical variability
  • Chemotaxonomy
  • Dibromotyrosine

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