Cinchona alkaloid induced chiral discrimination for the determination of the enantiomeric composition of α-trifluoromethylated-hydroxyl compounds by 19F NMR spectroscopy

Abid Shaikh; Béla Török

doi:10.1016/j.tetasy.2005.02.034

Cinchona alkaloid induced chiral discrimination for the determination of the enantiomeric composition of α-trifluoromethylated-hydroxyl compounds by ¹⁹F NMR spectroscopy

Abid Shaikh, Béla Török

Biochemistry, Chemistry & Physics

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The determination of the enantiomeric composition of α- trifluoromethylated-hydroxyl compounds using cinchona alkaloids as chiral selectors is described. The interaction between the alkaloid and trifluoromethylated-hydroxyl compounds converted the enantiotopic nuclei to diastereotopic nuclei observed by ¹⁹F NMR spectroscopy. A wide variety of target molecules have been studied to highlight the broad applicability of the method.

Original language	English
Pages (from-to)	1547-1555
Number of pages	9
Journal	Tetrahedron: Asymmetry
Volume	16
Issue number	8
DOIs	https://doi.org/10.1016/j.tetasy.2005.02.034
State	Published - Apr 18 2005

Scopus Subject Areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1016/j.tetasy.2005.02.034

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title = "Cinchona alkaloid induced chiral discrimination for the determination of the enantiomeric composition of α-trifluoromethylated-hydroxyl compounds by 19F NMR spectroscopy",

abstract = "The determination of the enantiomeric composition of α- trifluoromethylated-hydroxyl compounds using cinchona alkaloids as chiral selectors is described. The interaction between the alkaloid and trifluoromethylated-hydroxyl compounds converted the enantiotopic nuclei to diastereotopic nuclei observed by 19F NMR spectroscopy. A wide variety of target molecules have been studied to highlight the broad applicability of the method.",

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Y1 - 2005/4/18

N2 - The determination of the enantiomeric composition of α- trifluoromethylated-hydroxyl compounds using cinchona alkaloids as chiral selectors is described. The interaction between the alkaloid and trifluoromethylated-hydroxyl compounds converted the enantiotopic nuclei to diastereotopic nuclei observed by 19F NMR spectroscopy. A wide variety of target molecules have been studied to highlight the broad applicability of the method.

AB - The determination of the enantiomeric composition of α- trifluoromethylated-hydroxyl compounds using cinchona alkaloids as chiral selectors is described. The interaction between the alkaloid and trifluoromethylated-hydroxyl compounds converted the enantiotopic nuclei to diastereotopic nuclei observed by 19F NMR spectroscopy. A wide variety of target molecules have been studied to highlight the broad applicability of the method.

UR - https://www.scopus.com/pages/publications/17044429735

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DO - 10.1016/j.tetasy.2005.02.034

M3 - Article

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JO - Tetrahedron: Asymmetry

JF - Tetrahedron: Asymmetry

IS - 8

ER -

Cinchona alkaloid induced chiral discrimination for the determination of the enantiomeric composition of α-trifluoromethylated-hydroxyl compounds by ¹⁹F NMR spectroscopy

Abstract

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