Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment

R. Premaratna; R. P.V.J. Rajapakse; T. G.A.N. Chandrasena; D. M. Nanayakkara; N. K.B.K.R.G.W. Bandara; S. A.M. Kularatna; M. E. Eremeeva; G. A. Dasch; H. J. de Silva

doi:10.1016/j.trstmh.2009.10.006

Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment

R. Premaratna, R. P.V.J. Rajapakse, T. G.A.N. Chandrasena, D. M. Nanayakkara, N. K.B.K.R.G.W. Bandara, S. A.M. Kularatna, M. E. Eremeeva, G. A. Dasch, H. J. de Silva

Biostatistics, Epidemiology & Environmental Health Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Twenty-eight febrile Sri Lankan patients with undiagnosed fever for 7 days after hospital admission, who responded to empirical treatment with doxycycline, were retrospectively investigated using microimmunofluorescence assay to verify whether they had rickettsial infection. Eleven (39%) patients were confirmed as having spotted fever group rickettsioses and 10 (36%) as having Orientia tsutsugamushi. Seven were negative for all tests. This suggests that greater use of doxycycline appears justified for patients with undiagnosed fever in settings where rickettsial diseases are endemic or re-emerging with inadequate diagnostic facilities.

Original language	English
Pages (from-to)	368-370
Number of pages	3
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	104
Issue number	5
DOIs	https://doi.org/10.1016/j.trstmh.2009.10.006
State	Published - May 2010

Scopus Subject Areas

Parasitology
Public Health, Environmental and Occupational Health
Infectious Diseases

Keywords

Doxycycline
Fever
Orientia tsutsugamushi
Rickettsia conorii
Rickettsia infections
Sri Lanka

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trstmh.2009.10.006

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Premaratna, R., Rajapakse, R. P. V. J., Chandrasena, T. G. A. N., Nanayakkara, D. M., Bandara, N. K. B. K. R. G. W., Kularatna, S. A. M., Eremeeva, M. E., Dasch, G. A., & de Silva, H. J. (2010). Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104(5), 368-370. https://doi.org/10.1016/j.trstmh.2009.10.006

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title = "Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment",

abstract = "Twenty-eight febrile Sri Lankan patients with undiagnosed fever for 7 days after hospital admission, who responded to empirical treatment with doxycycline, were retrospectively investigated using microimmunofluorescence assay to verify whether they had rickettsial infection. Eleven (39%) patients were confirmed as having spotted fever group rickettsioses and 10 (36%) as having Orientia tsutsugamushi. Seven were negative for all tests. This suggests that greater use of doxycycline appears justified for patients with undiagnosed fever in settings where rickettsial diseases are endemic or re-emerging with inadequate diagnostic facilities.",

keywords = "Doxycycline, Fever, Orientia tsutsugamushi, Rickettsia conorii, Rickettsia infections, Sri Lanka",

author = "R. Premaratna and Rajapakse, {R. P.V.J.} and Chandrasena, {T. G.A.N.} and Nanayakkara, {D. M.} and Bandara, {N. K.B.K.R.G.W.} and Kularatna, {S. A.M.} and Eremeeva, {M. E.} and Dasch, {G. A.} and {de Silva}, {H. J.}",

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doi = "10.1016/j.trstmh.2009.10.006",

language = "English",

volume = "104",

pages = "368--370",

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Premaratna, R, Rajapakse, RPVJ, Chandrasena, TGAN, Nanayakkara, DM, Bandara, NKBKRGW, Kularatna, SAM, Eremeeva, ME, Dasch, GA & de Silva, HJ 2010, 'Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 104, no. 5, pp. 368-370. https://doi.org/10.1016/j.trstmh.2009.10.006

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T1 - Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment

AU - Premaratna, R.

AU - Rajapakse, R. P.V.J.

AU - Chandrasena, T. G.A.N.

AU - Nanayakkara, D. M.

AU - Bandara, N. K.B.K.R.G.W.

AU - Kularatna, S. A.M.

AU - Eremeeva, M. E.

AU - Dasch, G. A.

AU - de Silva, H. J.

PY - 2010/5

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AB - Twenty-eight febrile Sri Lankan patients with undiagnosed fever for 7 days after hospital admission, who responded to empirical treatment with doxycycline, were retrospectively investigated using microimmunofluorescence assay to verify whether they had rickettsial infection. Eleven (39%) patients were confirmed as having spotted fever group rickettsioses and 10 (36%) as having Orientia tsutsugamushi. Seven were negative for all tests. This suggests that greater use of doxycycline appears justified for patients with undiagnosed fever in settings where rickettsial diseases are endemic or re-emerging with inadequate diagnostic facilities.

KW - Doxycycline

KW - Fever

KW - Orientia tsutsugamushi

KW - Rickettsia conorii

KW - Rickettsia infections

KW - Sri Lanka

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JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

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Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment

Abstract

Scopus Subject Areas

Keywords

UN SDGs

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