Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats

Taku Sugawara; Fengshan Yu; Li Ma; Carleton J.C. Hsia; Pak H. Chan

doi:10.1097/00001756-200111160-00047

Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats

Taku Sugawara, Fengshan Yu, Li Ma, Carleton J.C. Hsia, Pak H. Chan

Biochemistry, Chemistry & Physics

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Nitroxides are antioxidants that are known to protect cells from oxidative damage. Polynitroxyl albumin (PNA) is a compound of human serum albumin covalently labeled with nitroxides that exhibits a prolonged half-life and an enhanced antioxidant activity. Adult male Sprague-Dawley rats were subjected to 90 min intraluminal middle cerebral artery occlusion and the drug was administered intravenously immediately or 2 h after reperfusion. The effects of the drug were evaluated 24 h after reperfusion. Infarct volume was significantly reduced in immediate (79% reduction) and delayed (53% reduction) PNA-treated groups. The efficacy of a single, delayed i.v. injection of PNA suggests that PNA has great promise in the treatment of acute human stroke.

Original language	English
Pages (from-to)	3609-3612
Number of pages	4
Journal	NeuroReport
Volume	12
Issue number	16
DOIs	https://doi.org/10.1097/00001756-200111160-00047
State	Published - Nov 16 2001

Scopus Subject Areas

General Neuroscience

Keywords

Delayed treatment
Focal cerebral ischemia
Neuroprotection
Nitroxides

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10.1097/00001756-200111160-00047

Cite this

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abstract = "Nitroxides are antioxidants that are known to protect cells from oxidative damage. Polynitroxyl albumin (PNA) is a compound of human serum albumin covalently labeled with nitroxides that exhibits a prolonged half-life and an enhanced antioxidant activity. Adult male Sprague-Dawley rats were subjected to 90 min intraluminal middle cerebral artery occlusion and the drug was administered intravenously immediately or 2 h after reperfusion. The effects of the drug were evaluated 24 h after reperfusion. Infarct volume was significantly reduced in immediate (79% reduction) and delayed (53% reduction) PNA-treated groups. The efficacy of a single, delayed i.v. injection of PNA suggests that PNA has great promise in the treatment of acute human stroke.",

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AU - Sugawara, Taku

AU - Yu, Fengshan

AU - Ma, Li

AU - Hsia, Carleton J.C.

AU - Chan, Pak H.

PY - 2001/11/16

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AB - Nitroxides are antioxidants that are known to protect cells from oxidative damage. Polynitroxyl albumin (PNA) is a compound of human serum albumin covalently labeled with nitroxides that exhibits a prolonged half-life and an enhanced antioxidant activity. Adult male Sprague-Dawley rats were subjected to 90 min intraluminal middle cerebral artery occlusion and the drug was administered intravenously immediately or 2 h after reperfusion. The effects of the drug were evaluated 24 h after reperfusion. Infarct volume was significantly reduced in immediate (79% reduction) and delayed (53% reduction) PNA-treated groups. The efficacy of a single, delayed i.v. injection of PNA suggests that PNA has great promise in the treatment of acute human stroke.

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Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats

Abstract

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Keywords

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