Electrophoretic transport of biomolecules through carbon nanotube membranes

Xinghua Sun; Xin Su; Ji Wu; Bruce J. Hinds

doi:10.1021/la104242p

Electrophoretic transport of biomolecules through carbon nanotube membranes

Xinghua Sun, Xin Su, Ji Wu, Bruce J. Hinds

Biochemistry, Chemistry, & Physics

University of Kentucky

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Electrophoretic transport of proteins across electrochemically oxidized multi-walled carbon nanotube (MWCNT) membranes has been investigated. A small charged protein, lysozyme, was successfully pumped across MWCNT membranes by an electric field while rejecting larger bovine serum albumin (BSA). Transport of lysozome was reduced by a factor of about 30 in comparison to bulk mobility and consistent with the prediction for hindered transport. Mobilities between 0.33 and 1.4 × 10^-9 m² V^-1 s^-1 were observed and are approximately 10-fold faster than comparable ordered nanoporous membranes and consistent with continuum models. For mixtures of BSA and lysozyme, complete rejection of BSA is seen with electrophoretic separations.

Original language	English
Pages (from-to)	3150-3156
Number of pages	7
Journal	Langmuir
Volume	27
Issue number	6
DOIs	https://doi.org/10.1021/la104242p
State	Published - Mar 15 2011

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title = "Electrophoretic transport of biomolecules through carbon nanotube membranes",

abstract = "Electrophoretic transport of proteins across electrochemically oxidized multi-walled carbon nanotube (MWCNT) membranes has been investigated. A small charged protein, lysozyme, was successfully pumped across MWCNT membranes by an electric field while rejecting larger bovine serum albumin (BSA). Transport of lysozome was reduced by a factor of about 30 in comparison to bulk mobility and consistent with the prediction for hindered transport. Mobilities between 0.33 and 1.4 × 10-9 m2 V-1 s-1 were observed and are approximately 10-fold faster than comparable ordered nanoporous membranes and consistent with continuum models. For mixtures of BSA and lysozyme, complete rejection of BSA is seen with electrophoretic separations.",

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AU - Sun, Xinghua

AU - Su, Xin

AU - Wu, Ji

AU - Hinds, Bruce J.

PY - 2011/3/15

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N2 - Electrophoretic transport of proteins across electrochemically oxidized multi-walled carbon nanotube (MWCNT) membranes has been investigated. A small charged protein, lysozyme, was successfully pumped across MWCNT membranes by an electric field while rejecting larger bovine serum albumin (BSA). Transport of lysozome was reduced by a factor of about 30 in comparison to bulk mobility and consistent with the prediction for hindered transport. Mobilities between 0.33 and 1.4 × 10-9 m2 V-1 s-1 were observed and are approximately 10-fold faster than comparable ordered nanoporous membranes and consistent with continuum models. For mixtures of BSA and lysozyme, complete rejection of BSA is seen with electrophoretic separations.

AB - Electrophoretic transport of proteins across electrochemically oxidized multi-walled carbon nanotube (MWCNT) membranes has been investigated. A small charged protein, lysozyme, was successfully pumped across MWCNT membranes by an electric field while rejecting larger bovine serum albumin (BSA). Transport of lysozome was reduced by a factor of about 30 in comparison to bulk mobility and consistent with the prediction for hindered transport. Mobilities between 0.33 and 1.4 × 10-9 m2 V-1 s-1 were observed and are approximately 10-fold faster than comparable ordered nanoporous membranes and consistent with continuum models. For mixtures of BSA and lysozyme, complete rejection of BSA is seen with electrophoretic separations.

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JO - Langmuir

JF - Langmuir

IS - 6

ER -

Electrophoretic transport of biomolecules through carbon nanotube membranes

Abstract

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