Electrospinning of Cisplatin-Loaded Cellulose Nanofibers for Cancer Drug Delivery

Saheem Absar; Mujibur R. Khan; Kyle Edwards; David M. Calamas

doi:10.1115/IMECE2014-37182

Electrospinning of Cisplatin-Loaded Cellulose Nanofibers for Cancer Drug Delivery

Saheem Absar, Mujibur R. Khan, Kyle Edwards, David M. Calamas

Mechanical Engineering

Georgia Southern University

Research output: Contribution to conference › Presentation

3 Scopus citations

Abstract

Cellulosic nanofibers have been electrospun with an antitumor agent Cisplatin. Cellulose acetate (CA) and Cisplatin were co-electrospun using a coaxial electrospinning system. For the outer sheath, a solution of 7.5wt% CA in Acetone and DMAc (2:1) was used. The inner core consisted of Cisplatin dissolved in DMF at a concentration of 5mg/ml. Drug-loaded nanofibers from Cellulose pulp (2wt%) dissolved in NMMO.H₂O were also produced. The solutions were electrospun in a high voltage electric field of 25-30 k V. Characterization of neat and drug-loaded nanofibers was performed using Scanning electron microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDS). The characterization studies have shown the formation of nanofibers having both sporadic beads with internal agglomeration and conjugation of Cisplatin on the nanofiber surfaces.

Original language	American English
DOIs	https://doi.org/10.1115/IMECE2014-37182
State	Published - Nov 14 2014
Event	Proceedings of the International Mechanical Engineering Congress and Exposition - Duration: Nov 14 2014 → …

Conference

Conference	Proceedings of the International Mechanical Engineering Congress and Exposition
Period	11/14/14 → …

Keywords

Anticancer drugs
Electrospinning
Nanofibers

DC Disciplines

Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1115/IMECE2014-37182License: Unspecified

https://doi.org/10.1115/IMECE2014-37182

Cite this

@conference{7f257bcbabac499483ed6b86f7265c1f,

title = "Electrospinning of Cisplatin-Loaded Cellulose Nanofibers for Cancer Drug Delivery",

abstract = "Cellulosic nanofibers have been electrospun with an antitumor agent Cisplatin. Cellulose acetate (CA) and Cisplatin were co-electrospun using a coaxial electrospinning system. For the outer sheath, a solution of 7.5wt% CA in Acetone and DMAc (2:1) was used. The inner core consisted of Cisplatin dissolved in DMF at a concentration of 5mg/ml. Drug-loaded nanofibers from Cellulose pulp (2wt%) dissolved in NMMO.H2O were also produced. The solutions were electrospun in a high voltage electric field of 25-30 k V. Characterization of neat and drug-loaded nanofibers was performed using Scanning electron microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDS). The characterization studies have shown the formation of nanofibers having both sporadic beads with internal agglomeration and conjugation of Cisplatin on the nanofiber surfaces.",

keywords = "Anticancer drugs, Electrospinning, Nanofibers",

author = "Saheem Absar and Khan, {Mujibur R.} and Kyle Edwards and Calamas, {David M.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 by ASME.; Proceedings of the International Mechanical Engineering Congress and Exposition ; Conference date: 14-11-2014",

year = "2014",

month = nov,

day = "14",

doi = "10.1115/IMECE2014-37182",

language = "American English",

}

TY - CONF

T1 - Electrospinning of Cisplatin-Loaded Cellulose Nanofibers for Cancer Drug Delivery

AU - Absar, Saheem

AU - Khan, Mujibur R.

AU - Edwards, Kyle

AU - Calamas, David M.

PY - 2014/11/14

Y1 - 2014/11/14

N2 - Cellulosic nanofibers have been electrospun with an antitumor agent Cisplatin. Cellulose acetate (CA) and Cisplatin were co-electrospun using a coaxial electrospinning system. For the outer sheath, a solution of 7.5wt% CA in Acetone and DMAc (2:1) was used. The inner core consisted of Cisplatin dissolved in DMF at a concentration of 5mg/ml. Drug-loaded nanofibers from Cellulose pulp (2wt%) dissolved in NMMO.H2O were also produced. The solutions were electrospun in a high voltage electric field of 25-30 k V. Characterization of neat and drug-loaded nanofibers was performed using Scanning electron microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDS). The characterization studies have shown the formation of nanofibers having both sporadic beads with internal agglomeration and conjugation of Cisplatin on the nanofiber surfaces.

AB - Cellulosic nanofibers have been electrospun with an antitumor agent Cisplatin. Cellulose acetate (CA) and Cisplatin were co-electrospun using a coaxial electrospinning system. For the outer sheath, a solution of 7.5wt% CA in Acetone and DMAc (2:1) was used. The inner core consisted of Cisplatin dissolved in DMF at a concentration of 5mg/ml. Drug-loaded nanofibers from Cellulose pulp (2wt%) dissolved in NMMO.H2O were also produced. The solutions were electrospun in a high voltage electric field of 25-30 k V. Characterization of neat and drug-loaded nanofibers was performed using Scanning electron microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDS). The characterization studies have shown the formation of nanofibers having both sporadic beads with internal agglomeration and conjugation of Cisplatin on the nanofiber surfaces.

KW - Anticancer drugs

KW - Electrospinning

KW - Nanofibers

UR - http://www.scopus.com/inward/record.url?scp=84926372746&partnerID=8YFLogxK

UR - https://digitalcommons.georgiasouthern.edu/mech-eng-facpubs/32

U2 - 10.1115/IMECE2014-37182

DO - 10.1115/IMECE2014-37182

M3 - Presentation

T2 - Proceedings of the International Mechanical Engineering Congress and Exposition

Y2 - 14 November 2014

ER -

Electrospinning of Cisplatin-Loaded Cellulose Nanofibers for Cancer Drug Delivery

Abstract

Conference

Keywords

DC Disciplines

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this