Epigenetics in Neurobehavioral Disease

Jannet Kocerha; Neha Aggarwal

doi:10.1016/B978-0-12-812215-0.00008-X

Epigenetics in Neurobehavioral Disease

Jannet Kocerha, Neha Aggarwal

Biochemistry, Chemistry & Physics

Research output: Contribution to book or proceeding › Chapter › peer-review

1 Scopus citations

Abstract

This chapter elaborates on the role of epigenetic mechanisms in the expression of neurobehavioral outcomes in psychiatric disease, including mood and psychotic disorders, addiction, and aberrant responses to stress, fear, and anxiety. These disorders provide resourceful models to uncover pathways that network core central nervous system functions with emergent human behaviors. This chapter discusses how current epigenetic paradigms for noncoding RNAs, DNA methylation, and histone modifications significantly influence development and progression of symptoms in afflicted patients.

Original language	English
Title of host publication	Epigenetics in Human Disease
Publisher	Elsevier
Pages	251-267
Number of pages	17
ISBN (Electronic)	9780128122150
ISBN (Print)	9780128123294
DOIs	https://doi.org/10.1016/B978-0-12-812215-0.00008-X
State	Published - Jan 1 2018

Scopus Subject Areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

Keywords

Antisense RNA
Circular RNA (circRNA)
DNA methylation
Epigenetics
Long noncoding RNA (lncRNA)
MicroRNA (miRNA)
Neurobehavior
Neurogenesis
Noncoding RNAs
Polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-812215-0.00008-X

Cite this

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abstract = "This chapter elaborates on the role of epigenetic mechanisms in the expression of neurobehavioral outcomes in psychiatric disease, including mood and psychotic disorders, addiction, and aberrant responses to stress, fear, and anxiety. These disorders provide resourceful models to uncover pathways that network core central nervous system functions with emergent human behaviors. This chapter discusses how current epigenetic paradigms for noncoding RNAs, DNA methylation, and histone modifications significantly influence development and progression of symptoms in afflicted patients.",

keywords = "Antisense RNA, Circular RNA (circRNA), DNA methylation, Epigenetics, Long noncoding RNA (lncRNA), MicroRNA (miRNA), Neurobehavior, Neurogenesis, Noncoding RNAs, Polymorphism",

author = "Jannet Kocerha and Neha Aggarwal",

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AU - Aggarwal, Neha

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AB - This chapter elaborates on the role of epigenetic mechanisms in the expression of neurobehavioral outcomes in psychiatric disease, including mood and psychotic disorders, addiction, and aberrant responses to stress, fear, and anxiety. These disorders provide resourceful models to uncover pathways that network core central nervous system functions with emergent human behaviors. This chapter discusses how current epigenetic paradigms for noncoding RNAs, DNA methylation, and histone modifications significantly influence development and progression of symptoms in afflicted patients.

KW - Antisense RNA

KW - Circular RNA (circRNA)

KW - DNA methylation

KW - Epigenetics

KW - Long noncoding RNA (lncRNA)

KW - MicroRNA (miRNA)

KW - Neurobehavior

KW - Neurogenesis

KW - Noncoding RNAs

KW - Polymorphism

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DO - 10.1016/B978-0-12-812215-0.00008-X

M3 - Chapter

AN - SCOPUS:85075118547

SN - 9780128123294

SP - 251

EP - 267

BT - Epigenetics in Human Disease

PB - Elsevier

ER -

Epigenetics in Neurobehavioral Disease

Abstract

Scopus Subject Areas

Keywords

UN SDGs

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