TY - JOUR
T1 - Evaluation of Humoral Immune Response in Adaptive Immunity in ALS Patients during Disease Progression
AU - Saleh, Islam A.
AU - Zesiewicz, Theresa
AU - Xie, Yong
AU - Sullivan, Kelly L.
AU - Miller, Amber M.
AU - Kuzmin-Nichols, Nicole
AU - Sanberg, Paul R.
AU - Garbuzova-Davis, Svitlana
PY - 2009/10/30
Y1 - 2009/10/30
N2 - In ALS, evidence suggests immune reactions in disease pathogenesis. Although immunological changes point to adaptive immune response, whether humoral or cellular response dominates during disease course is unknown. The study aim was to evaluate humoral immune response in ALS patients during disease progression. Circulating immune complexes (CICs), IgG, and IgM in sera of ALS patients and matching controls were evaluated after each of two visits. Results showed significantly elevated CICs and IgG in ALS patient sera. CICs decreased to control levels at the second visit, yet IgG remained higher than controls. Serum IgM was within normal range. Results suggest a humoral immune response initiating adaptive immunity in ALS, however, cellular immune response needs verification.
AB - In ALS, evidence suggests immune reactions in disease pathogenesis. Although immunological changes point to adaptive immune response, whether humoral or cellular response dominates during disease course is unknown. The study aim was to evaluate humoral immune response in ALS patients during disease progression. Circulating immune complexes (CICs), IgG, and IgM in sera of ALS patients and matching controls were evaluated after each of two visits. Results showed significantly elevated CICs and IgG in ALS patient sera. CICs decreased to control levels at the second visit, yet IgG remained higher than controls. Serum IgM was within normal range. Results suggest a humoral immune response initiating adaptive immunity in ALS, however, cellular immune response needs verification.
KW - Amyotrophic lateral sclerosis
KW - Circulating immune complexes
KW - Humoral immune response
KW - IgG
KW - IgM
UR - https://doi.org/10.1016/j.jneuroim.2009.07.011
U2 - 10.1016/j.jneuroim.2009.07.011
DO - 10.1016/j.jneuroim.2009.07.011
M3 - Article
SN - 0165-5728
VL - 215
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -