Evolutionary and Comparative Analysis of Aquaporin Water Channel Genes in Fish

Christopher P. Cutler, Lara Meischke, Gordon Cramb

Research output: Contribution to journalArticlepeer-review

Abstract

The role of aquaporin water channels in some teleost fish has been described for some (orthologues of mammalian) aquaporins, especially aquaporins 1 (AQP) 0, 1 and 3, however to date the role of aquaporins in other more ancient fish lineages such as the Elasmobranches and Agnathans remains almost completely uninvestigated. The goal of this project is to identify homologous aquaporin genes from Elasmobranches (dogfish shark; Squalus acanthias and bullshark; Carcharhinus leucas ) and Agnathan (hagfish; Myxine glutinosa ) species, and from ancient teleost fish species (eels; Anguilla anguilla and Anguilla rostrata ) in order to answer a number of questions regarding the kind of aquaporin homologues that are present in these species and their relationship to aquaporins found in higher vertebrates. A longer term objective is begin to discern the physiological role, that any aquaporins found in Agnatha, Elasmobranches or Teleosts play.

Original languageAmerican English
JournalThe Bulletin: Mount Desert Island Biological Laboratory
Volume44
StatePublished - Jan 1 2005

Disciplines

  • Biochemistry, Biophysics, and Structural Biology
  • Biology

Keywords

  • Aquaporin water channel
  • Comparative analysis
  • Evolutionary
  • Fish
  • Genes

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