Abstract
Single isomers of the furanylidene system 8 were synthesized in four steps. The synthesis begins with the dianion of β-keto carbonyls and culminates in a mild, tandem desilylationcyclization reaction using tosylic acid. Compounds synthesized in this study have the potential for further diversification at the alkyne, carbonyl and enol-ether moieties. Hence, the furanylidenes from this study are prospective building blocks for biologically active, furan-containing natural products and their analogs. 2011 ·
Original language | American English |
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Journal | Heterocyclic Communications |
Volume | 17 |
DOIs | |
State | Published - Jan 1 2011 |
Disciplines
- Chemistry
- Organic Chemistry
Keywords
- Desilylation
- Furanylidene
- Silyl ether
- Tosylic acid