Abstract
Genomic profiling and in vitro analysis of microRNAs in neurodegenerative disorders The aims of this proposal were to uncover novel noncoding microRNA-mRNA mechanisms in dementia caused by mutations in the Progranulin gene. We uncovered specific noncoding RNA-mediated pathways in response to Progranulin haploinsufficiency in the frontal cortex of brains from a large cohort of patients.
| Original language | American English |
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| State | Published - May 1 2009 |
DC Disciplines
- Biochemistry
- Neuroscience and Neurobiology