Abstract
This project will find the effects of 2-aminoanthracene on the in utero pups after being ingested by the dams. The goal of this project is to determine if the same systemic injuries caused by 2-aminoanthracene on adult rats will also occur in the in utero pups after ingestion by their dams. This information is useful to determine the effects of pregnant humans ingesting 2-aminoanthracene. This could have effects on both the pregnant mother as well as her unborn child. These effects could last into adulthood and encourage or even cause insulin resistance or Type-II diabetes. This project will explore the histology, fatty liver, lipids, and genes expressed in the liver: SOCS1, SREBP1C, CD36, AMPK, PCK1, FASN, HNF4a, and PPARa.
Original language | American English |
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State | Published - Mar 22 2015 |
Event | American Chemical Society National Meeting and Exposition (ACS) - Duration: Mar 22 2015 → … |
Conference
Conference | American Chemical Society National Meeting and Exposition (ACS) |
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Period | 03/22/15 → … |
Disciplines
- Chemistry
Keywords
- 2-aminoanthracene
- Exposed
- Hepatic gene expression
- Metabolic syndrome
- Pups
- Susceptibility
- Utero