Abstract
An enantioselective organocatalytic microwave-assisted method for the addition of ethyl trifluoropyruvate to ketones to synthesize highly enantiomerically enriched organofluorine synthons is described. Besides the high yields, diastereo- and enantioselectivities, the most important observation is that the use of microwave irradiation at subzero temperatures proved to be beneficial. The results indicate that subzero temperature microwave chemistry is a potentially intriguing tool for asymmetric synthesis.
| Original language | American English |
|---|---|
| Journal | Catalysis Letters |
| Volume | 131 |
| State | Published - 2009 |
Keywords
- Asymmetric synthesis
- Microwave irradiation
- Organocatalysis
- Organofluorine
- Subzero temperature
DC Disciplines
- Chemistry