Abstract
An enantioselective organocatalytic microwave-assisted method for the addition of ethyl trifluoropyruvate to ketones to synthesize highly enantiomerically enriched organofluorine synthons is described. Besides the high yields, diastereo- and enantioselectivities, the most important observation is that the use of microwave irradiation at subzero temperatures proved to be beneficial. The results indicate that subzero temperature microwave chemistry is a potentially intriguing tool for asymmetric synthesis.
| Original language | English |
|---|---|
| Pages (from-to) | 432-439 |
| Number of pages | 8 |
| Journal | Catalysis Letters |
| Volume | 131 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - Sep 2009 |
Scopus Subject Areas
- Catalysis
- General Chemistry
Keywords
- Asymmetric synthesis
- Microwave irradiation
- Organocatalysis
- Organofluorine
- Subzero temperature
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