Hodge Solid- Phase Organic Synthesis and Combinatorial Chemistry: A Laboratory Preparation of Oligopeptides

Karelle Aiken; George A. Truran; Thomas R. Fleming; Peter J. Webb; J. Markgraf

Hodge Solid- Phase Organic Synthesis and Combinatorial Chemistry: A Laboratory Preparation of Oligopeptides

Karelle Aiken
, George A. Truran
, Thomas R. Fleming
, Peter J. Webb
, J. Markgraf

Biochemistry, Chemistry & Physics

Research output: Contribution to journal › Article › peer-review

Abstract

The principles and practice of solid-phase organic synthesis and combinatorial chemistry are utilized in a laboratory preparation of oligopeptides. A parallel synthesis scheme is used to generate a series of tripeptides. A divergent synthesis scheme is used to prepare two pentapeptides, one of which is leucine enkephalin, a neurotransmitter known to be an analgesic agent.

Original language	American English
Journal	Journal of Chemical Education
Volume	79
State	Published - 2002

Disciplines

Chemistry
Organic Chemistry

Keywords

Organic chemistry

Cite this

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title = "Hodge Solid- Phase Organic Synthesis and Combinatorial Chemistry: A Laboratory Preparation of Oligopeptides",

abstract = "The principles and practice of solid-phase organic synthesis and combinatorial chemistry are utilized in a laboratory preparation of oligopeptides. A parallel synthesis scheme is used to generate a series of tripeptides. A divergent synthesis scheme is used to prepare two pentapeptides, one of which is leucine enkephalin, a neurotransmitter known to be an analgesic agent.",

keywords = "Organic chemistry",

author = "Karelle Aiken and Truran, \{George A.\} and Fleming, \{Thomas R.\} and Webb, \{Peter J.\} and J. Markgraf",

year = "2002",

language = "American English",

volume = "79",

journal = "Journal of Chemical Education",

issn = "0021-9584",

publisher = "American Chemical Society",

}

TY - JOUR

T1 - Hodge Solid- Phase Organic Synthesis and Combinatorial Chemistry

T2 - A Laboratory Preparation of Oligopeptides

AU - Aiken, Karelle

AU - Truran, George A.

AU - Fleming, Thomas R.

AU - Webb, Peter J.

AU - Markgraf, J.

PY - 2002

Y1 - 2002

N2 - The principles and practice of solid-phase organic synthesis and combinatorial chemistry are utilized in a laboratory preparation of oligopeptides. A parallel synthesis scheme is used to generate a series of tripeptides. A divergent synthesis scheme is used to prepare two pentapeptides, one of which is leucine enkephalin, a neurotransmitter known to be an analgesic agent.

AB - The principles and practice of solid-phase organic synthesis and combinatorial chemistry are utilized in a laboratory preparation of oligopeptides. A parallel synthesis scheme is used to generate a series of tripeptides. A divergent synthesis scheme is used to prepare two pentapeptides, one of which is leucine enkephalin, a neurotransmitter known to be an analgesic agent.

KW - Organic chemistry

M3 - Article

SN - 0021-9584

VL - 79

JO - Journal of Chemical Education

JF - Journal of Chemical Education

ER -

Hodge Solid- Phase Organic Synthesis and Combinatorial Chemistry: A Laboratory Preparation of Oligopeptides

Abstract

Disciplines

Keywords

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