@inproceedings{b8b6d7d4fa7844489455a9fa2c80ca84,
title = "Identifying and testing of signatures for non-volatile biomolecules using tandem mass spectra",
abstract = "Identification of volatile and semi-volatile molecules using traditional election ionization mass spectrometry has been successful. The major contributor to this success is the reproduceability of the mass spectra, which allow identification of components based on comparison of fragmentation patterns within very large databases. However, this approach is not useful for the identification of typical non-volatile biomolecules. Tandem mass spectrometry with collision induced dissociation (CID) has ' the potential to provide structure-specific fragmentation from non-volatile biomolecules. The recognition of these molecules based on CID is not an easy task, since the spectra generated for a given molecule are not as reproducible as in traditional electron ionization mass spectrometry. Also, the rules governing the formation of CID produced ions are not completely understood. In this study we investigate the use of the Kohonen Self-Organized Mapping (SOM) neural network to generate and test signatures (fragmentation patterns) for a given set of non-volatile biomolecules using spectra generated by tandem mass spectrometry with CID. The signatures then may be used as a discriminator for identifying unknown non-volatile biomolecules.",
keywords = "Kohonen self organizing map and classification, Pattern generation, Tandem mass spectrometry",
author = "Hashemi, {Ray R.} and Schafer, {Theresa M.} and Hinson, {William G.} and Lay, {Jackson O.}",
year = "1996",
month = feb,
day = "18",
doi = "10.1145/331119.331140",
language = "English",
series = "Proceedings of the ACM Symposium on Applied Computing",
publisher = "Association for Computing Machinery",
pages = "44--49",
editor = "Carroll, {Janice H.} and George, {K. M.} and Jim Hightower and Dave Oppenheim",
booktitle = "Proceedings of the 1996 ACM Symposium on Applied Computing, SAC 1996",
address = "United States",
note = "1996 ACM Symposium on Applied Computing, SAC 1996 ; Conference date: 17-02-1996 Through 19-02-1996",
}