Abstract
The immune response of arthropod vectors plays a key role in the spread and transmission of vector-borne diseases. Although fleas transmit several human pathogens (e.g., Bartonella henselae, Rickettsia felis, R. typhi, and Yersinia pestis), few studies have examined how these vectors respond to infection. In hematophagous arthropods, imbibed pathogens must survive the hostile environment of blood meal digestion, which includes proteolytic digestive enzymes, protease inhibitors and expression of genes associated with protection of epithelial linings. Additionally, insect epithelial cells exhibit local immune defense against ingested pathogens by producing antimicrobial peptides and reactive oxygen species. This review details these and other aspects of insect immunity as it relates to fleas, with an emphasis on the gut immune response to two blood-borne pathogens, R. typhi and Y. pestis.
Original language | English |
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Pages (from-to) | 76-79 |
Number of pages | 4 |
Journal | Developmental and Comparative Immunology |
Volume | 98 |
DOIs | |
State | Published - Sep 2019 |
Scopus Subject Areas
- Immunology
- Developmental Biology
Keywords
- Ctenocephalides felis
- Immunology
- Insect
- Pathogen
- Vector
- Xenopsylla cheopis