Isolation of Rickettsia akari from eschars of patients with rickettsialpox

Christopher D. Paddock, Tamara Koss, Marina E. Eremeeva, Gregory A. Dasch, Sherif R. Zaki, John W. Sumner

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Rickettsialpox is a cosmopolitan, mite-borne, spotted fever rickettsiosis caused by Rickettsia akari. The disease is characterized by a primary eschar, fever, and a papulovesicular rash. Rickettsialpox was first identified in New York City in 1946 and the preponderance of recognized cases in the United States continues to originate from this large metropolitan center. The most recently isolated U.S. strain of R. akari was obtained more than a half century ago. We describe the culture and initial characterization of five contemporaneous isolates of R. akari obtained from eschar biopsy specimens from New York City patients with rickettsialpox. This work emphasizes the importance and utility of culture-and molecular-based methods for the diagnosis of rickettsialpox and other eschar-associated illnesses.

Original languageEnglish
Pages (from-to)732-738
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume75
Issue number4
DOIs
StatePublished - 2006

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