Isomorphism and similarity for 2-generation pedigrees

Haitao Jiang, Guohui Lin, Weitian Tong, Daming Zhu, Binhai Zhu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We consider the emerging problem of comparing the similarity between (unlabeled) pedigrees. More specifically, we focus on the simplest pedigrees, namely, the 2-generation pedigrees. We show that the isomorphism testing for two 2-generation pedigrees is GI-hard. If the 2-generation pedigrees are monogamous (i.e., each individual at level-1 can mate with exactly one partner) then the isomorphism testing problem can be solved in polynomial time. We then consider the problem by relaxing it into an NP-complete decomposition problem which can be formulated as the Minimum Common Integer Pair Partition (MCIPP) problem, which we show to be FPT by exploiting a property of the optimal solution. While there is still some difficulty to overcome, this lays down a solid foundation for this research.

Original languageEnglish
Article numberS7
JournalBMC Bioinformatics
Volume16
Issue number5
DOIs
StatePublished - Mar 18 2015

Keywords

  • FPT algorithms
  • Graph isomorphism
  • NP-complete
  • Pedigree similarity

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