Memory Impairment and Mortality in a National Cohort of Older Persons

Joseph Lowry; Anissa Austin; Hasan Al-Sayegh; Ngosi Michael; Jian Zhang

Memory Impairment and Mortality in a National Cohort of Older Persons

Joseph Lowry, Anissa Austin, Hasan Al-Sayegh, Ngosi Michael, Jian Zhang

Biostatistics, Epidemiology, & Environmental Health Sciences

Georgia Southern University

Research output: Contribution to conference › Presentation

Abstract

<div class="line" id="line-5"> <b> Background: </b> The mortality pattern of individuals with impaired verbal memory (IVM) has not yet been well described. We sought to describe the risk of all&hyphen;causes, as well as specific causes of death associated with IVM.</div><div class="line" id="line-8"> <br/></div><div class="line" id="line-10"> <b> Method: </b> We used the data of 4151 nationally representative adults ≥60 years old who participated in the third National Health and Nutrition Examination Survey, 1988–1994, and completed one non&hyphen;contextual (i.e., word list memory) and one contextual delayed&hyphen;recall tests (i.e., short story recall). The participants were passively followed up through 31 December 2006. We determined the hazard ratio of death from all&hyphen;causes and specific cause through Cox proportional hazard regression.</div><div class="line" id="line-13"> <br/></div><div class="line" id="line-15"> <b> Results: </b> Severe and moderate IVM were present in 268 (6.5%) and 495 (11.9%) participants at baseline survey, and 2550 deaths occurred by the end of 18&hyphen;year follow&hyphen;up (median = 12 years). The medians of survival time adjusted for all&hyphen;causes death were 6.17(95%CI: 5.50, 6.92), 9.50 (8.92, 10.25), and 13.17 (12.75, 13.58) years, respectively for the individuals with severe, moderate, and no IVM. Severe IVM was significantly associated with death from cardio&hyphen;cerebral vascular diseases [hazard ratio = 1.70, 95%CI = (1.36–2.12)], stroke [2.60 (1.69–3.99)], and Alzheimer's disease [3.50 (1.40–8.76)]. The shortened survival time of the participants with IVM was mainly driven by the deaths of cerebral&hyphen;cardiovascular diseases, which accounted for almost half of all deaths.</div><div class="line" id="line-18"> <br/></div><div class="line" id="line-20"> <b> Conclusion: </b> The predictability of memory scores to early cerebral&hyphen;cardiovascular deaths demonstrated that central challenge among individuals with cognitive impairment was cardiovascular diseases management.</div>

Original language	American English
State	Published - Apr 12 2012
Event	Society of Behavioral Medicine Annual Meeting and Scientific Sessions (SBM) - Duration: Apr 22 2015 → …

Conference

Conference	Society of Behavioral Medicine Annual Meeting and Scientific Sessions (SBM)
Period	04/22/15 → …

Keywords

Cardiovascular disease
Follow-up
Memory
Mortality

DC Disciplines

Epidemiology
Public Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@conference{8b38071ea12348dc8f5174596170abbd,

title = "Memory Impairment and Mortality in a National Cohort of Older Persons",

abstract = " Background: The mortality pattern of individuals with impaired verbal memory (IVM) has not yet been well described. We sought to describe the risk of all&hyphen;causes, as well as specific causes of death associated with IVM. Method: We used the data of 4151 nationally representative adults ≥60 years old who participated in the third National Health and Nutrition Examination Survey, 1988–1994, and completed one non&hyphen;contextual (i.e., word list memory) and one contextual delayed&hyphen;recall tests (i.e., short story recall). The participants were passively followed up through 31 December 2006. We determined the hazard ratio of death from all&hyphen;causes and specific cause through Cox proportional hazard regression. Results: Severe and moderate IVM were present in 268 (6.5%) and 495 (11.9%) participants at baseline survey, and 2550 deaths occurred by the end of 18&hyphen;year follow&hyphen;up (median = 12 years). The medians of survival time adjusted for all&hyphen;causes death were 6.17(95%CI: 5.50, 6.92), 9.50 (8.92, 10.25), and 13.17 (12.75, 13.58) years, respectively for the individuals with severe, moderate, and no IVM. Severe IVM was significantly associated with death from cardio&hyphen;cerebral vascular diseases [hazard ratio = 1.70, 95%CI = (1.36–2.12)], stroke [2.60 (1.69–3.99)], and Alzheimer's disease [3.50 (1.40–8.76)]. The shortened survival time of the participants with IVM was mainly driven by the deaths of cerebral&hyphen;cardiovascular diseases, which accounted for almost half of all deaths. Conclusion: The predictability of memory scores to early cerebral&hyphen;cardiovascular deaths demonstrated that central challenge among individuals with cognitive impairment was cardiovascular diseases management.",

keywords = "Cardiovascular disease, Follow-up, Memory, Mortality",

author = "Joseph Lowry and Anissa Austin and Hasan Al-Sayegh and Ngosi Michael and Jian Zhang",

year = "2012",

month = apr,

day = "12",

language = "American English",

note = "Society of Behavioral Medicine Annual Meeting and Scientific Sessions (SBM) ; Conference date: 22-04-2015",

}

TY - CONF

T1 - Memory Impairment and Mortality in a National Cohort of Older Persons

AU - Lowry, Joseph

AU - Austin, Anissa

AU - Al-Sayegh, Hasan

AU - Michael, Ngosi

AU - Zhang, Jian

PY - 2012/4/12

Y1 - 2012/4/12

N2 - Background: The mortality pattern of individuals with impaired verbal memory (IVM) has not yet been well described. We sought to describe the risk of all&hyphen;causes, as well as specific causes of death associated with IVM. Method: We used the data of 4151 nationally representative adults ≥60 years old who participated in the third National Health and Nutrition Examination Survey, 1988–1994, and completed one non&hyphen;contextual (i.e., word list memory) and one contextual delayed&hyphen;recall tests (i.e., short story recall). The participants were passively followed up through 31 December 2006. We determined the hazard ratio of death from all&hyphen;causes and specific cause through Cox proportional hazard regression. Results: Severe and moderate IVM were present in 268 (6.5%) and 495 (11.9%) participants at baseline survey, and 2550 deaths occurred by the end of 18&hyphen;year follow&hyphen;up (median = 12 years). The medians of survival time adjusted for all&hyphen;causes death were 6.17(95%CI: 5.50, 6.92), 9.50 (8.92, 10.25), and 13.17 (12.75, 13.58) years, respectively for the individuals with severe, moderate, and no IVM. Severe IVM was significantly associated with death from cardio&hyphen;cerebral vascular diseases [hazard ratio = 1.70, 95%CI = (1.36–2.12)], stroke [2.60 (1.69–3.99)], and Alzheimer's disease [3.50 (1.40–8.76)]. The shortened survival time of the participants with IVM was mainly driven by the deaths of cerebral&hyphen;cardiovascular diseases, which accounted for almost half of all deaths. Conclusion: The predictability of memory scores to early cerebral&hyphen;cardiovascular deaths demonstrated that central challenge among individuals with cognitive impairment was cardiovascular diseases management.

AB - Background: The mortality pattern of individuals with impaired verbal memory (IVM) has not yet been well described. We sought to describe the risk of all&hyphen;causes, as well as specific causes of death associated with IVM. Method: We used the data of 4151 nationally representative adults ≥60 years old who participated in the third National Health and Nutrition Examination Survey, 1988–1994, and completed one non&hyphen;contextual (i.e., word list memory) and one contextual delayed&hyphen;recall tests (i.e., short story recall). The participants were passively followed up through 31 December 2006. We determined the hazard ratio of death from all&hyphen;causes and specific cause through Cox proportional hazard regression. Results: Severe and moderate IVM were present in 268 (6.5%) and 495 (11.9%) participants at baseline survey, and 2550 deaths occurred by the end of 18&hyphen;year follow&hyphen;up (median = 12 years). The medians of survival time adjusted for all&hyphen;causes death were 6.17(95%CI: 5.50, 6.92), 9.50 (8.92, 10.25), and 13.17 (12.75, 13.58) years, respectively for the individuals with severe, moderate, and no IVM. Severe IVM was significantly associated with death from cardio&hyphen;cerebral vascular diseases [hazard ratio = 1.70, 95%CI = (1.36–2.12)], stroke [2.60 (1.69–3.99)], and Alzheimer's disease [3.50 (1.40–8.76)]. The shortened survival time of the participants with IVM was mainly driven by the deaths of cerebral&hyphen;cardiovascular diseases, which accounted for almost half of all deaths. Conclusion: The predictability of memory scores to early cerebral&hyphen;cardiovascular deaths demonstrated that central challenge among individuals with cognitive impairment was cardiovascular diseases management.

KW - Cardiovascular disease

KW - Follow-up

KW - Memory

KW - Mortality

UR - https://www.sbm.org/meetings/2012/final-program

M3 - Presentation

T2 - Society of Behavioral Medicine Annual Meeting and Scientific Sessions (SBM)

Y2 - 22 April 2015

ER -

Memory Impairment and Mortality in a National Cohort of Older Persons

Abstract

Conference

Keywords

DC Disciplines

UN SDGs

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