Microscale Electrolytic Fluorinations of 4-Nitrotoluene - Cell Construction, Computer Monitor and Control, and Chemistry

S. C. Savett; S. M. Lee; A. Z. Bradley; S. P. Kneizys; J. M. Lobue; W. J. Middleton

doi:10.1006/mchj.1993.1090

Microscale Electrolytic Fluorinations of 4-Nitrotoluene - Cell Construction, Computer Monitor and Control, and Chemistry

S. C. Savett, S. M. Lee, A. Z. Bradley, S. P. Kneizys, J. M. Lobue, W. J. Middleton

Biochemistry, Chemistry & Physics

Ursinus College

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

An electrochemical microcell that can utilize a 70:30 mixture of HF and pyridine as both the solvent and the supporting electrolyte was constructed and interfaced with a computer for monitoring and control. 4-Nitrotoluene was selectively fluorinated in the cell in good yield and good conversion to give an 83:17 mixture of two monofluoro products, α-fluoro-4-nitrotoluene and 2-fluoro-5-nitrotoluene (a product of rearrangement).

Original language	English
Pages (from-to)	192-199
Number of pages	8
Journal	Microchemical Journal
Volume	48
Issue number	2
DOIs	https://doi.org/10.1006/mchj.1993.1090
State	Published - Oct 1993

Scopus Subject Areas

Analytical Chemistry
Spectroscopy

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title = "Microscale Electrolytic Fluorinations of 4-Nitrotoluene - Cell Construction, Computer Monitor and Control, and Chemistry",

abstract = "An electrochemical microcell that can utilize a 70:30 mixture of HF and pyridine as both the solvent and the supporting electrolyte was constructed and interfaced with a computer for monitoring and control. 4-Nitrotoluene was selectively fluorinated in the cell in good yield and good conversion to give an 83:17 mixture of two monofluoro products, α-fluoro-4-nitrotoluene and 2-fluoro-5-nitrotoluene (a product of rearrangement).",

author = "Savett, \{S. C.\} and Lee, \{S. M.\} and Bradley, \{A. Z.\} and Kneizys, \{S. P.\} and Lobue, \{J. M.\} and Middleton, \{W. J.\}",

year = "1993",

month = oct,

doi = "10.1006/mchj.1993.1090",

language = "English",

volume = "48",

pages = "192--199",

journal = "Microchemical Journal",

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T1 - Microscale Electrolytic Fluorinations of 4-Nitrotoluene - Cell Construction, Computer Monitor and Control, and Chemistry

AU - Savett, S. C.

AU - Lee, S. M.

AU - Bradley, A. Z.

AU - Kneizys, S. P.

AU - Lobue, J. M.

AU - Middleton, W. J.

PY - 1993/10

Y1 - 1993/10

N2 - An electrochemical microcell that can utilize a 70:30 mixture of HF and pyridine as both the solvent and the supporting electrolyte was constructed and interfaced with a computer for monitoring and control. 4-Nitrotoluene was selectively fluorinated in the cell in good yield and good conversion to give an 83:17 mixture of two monofluoro products, α-fluoro-4-nitrotoluene and 2-fluoro-5-nitrotoluene (a product of rearrangement).

AB - An electrochemical microcell that can utilize a 70:30 mixture of HF and pyridine as both the solvent and the supporting electrolyte was constructed and interfaced with a computer for monitoring and control. 4-Nitrotoluene was selectively fluorinated in the cell in good yield and good conversion to give an 83:17 mixture of two monofluoro products, α-fluoro-4-nitrotoluene and 2-fluoro-5-nitrotoluene (a product of rearrangement).

UR - https://www.scopus.com/pages/publications/0000860845

U2 - 10.1006/mchj.1993.1090

DO - 10.1006/mchj.1993.1090

M3 - Article

AN - SCOPUS:0000860845

SN - 0026-265X

VL - 48

SP - 192

EP - 199

JO - Microchemical Journal

JF - Microchemical Journal

IS - 2

ER -

Microscale Electrolytic Fluorinations of 4-Nitrotoluene - Cell Construction, Computer Monitor and Control, and Chemistry

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