Microwave-assisted preparation of trifluoroacetaldehyde (fluoral): isolation and applications

Shainaz M. Landge; Dmitry A. Borkin; Béla Török

doi:10.1016/j.tetlet.2007.06.170

Microwave-assisted preparation of trifluoroacetaldehyde (fluoral): isolation and applications

Shainaz M. Landge, Dmitry A. Borkin, Béla Török

Biochemistry, Chemistry & Physics

University of Massachusetts

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

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Abstract

A novel method for the preparation of trifluoroacetaldehyde (fluoral, TFAc, CF₃CHO) from commercially available trifluoroacetaldehyde ethylhemiacetal (TFAE) by microwave irradiation is described. The isolation, characterization and reaction of fluoral with various nucleophiles were studied to verify the diverse applicability of this new method.

Original language	English
Pages (from-to)	6372-6376
Number of pages	5
Journal	Tetrahedron Letters
Volume	48
Issue number	36
DOIs	https://doi.org/10.1016/j.tetlet.2007.06.170
State	Published - Sep 3 2007

Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Fluoral
Microwave irradiation
Trifluoroacetaldehyde
Trifluoromethylated alcohols

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10.1016/j.tetlet.2007.06.170

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abstract = "A novel method for the preparation of trifluoroacetaldehyde (fluoral, TFAc, CF3CHO) from commercially available trifluoroacetaldehyde ethylhemiacetal (TFAE) by microwave irradiation is described. The isolation, characterization and reaction of fluoral with various nucleophiles were studied to verify the diverse applicability of this new method.",

keywords = "Fluoral, Microwave irradiation, Trifluoroacetaldehyde, Trifluoromethylated alcohols",

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AU - Landge, Shainaz M.

AU - Borkin, Dmitry A.

AU - Török, Béla

PY - 2007/9/3

Y1 - 2007/9/3

N2 - A novel method for the preparation of trifluoroacetaldehyde (fluoral, TFAc, CF3CHO) from commercially available trifluoroacetaldehyde ethylhemiacetal (TFAE) by microwave irradiation is described. The isolation, characterization and reaction of fluoral with various nucleophiles were studied to verify the diverse applicability of this new method.

AB - A novel method for the preparation of trifluoroacetaldehyde (fluoral, TFAc, CF3CHO) from commercially available trifluoroacetaldehyde ethylhemiacetal (TFAE) by microwave irradiation is described. The isolation, characterization and reaction of fluoral with various nucleophiles were studied to verify the diverse applicability of this new method.

KW - Fluoral

KW - Microwave irradiation

KW - Trifluoroacetaldehyde

KW - Trifluoromethylated alcohols

UR - http://www.scopus.com/inward/record.url?scp=34547691652&partnerID=8YFLogxK

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DO - 10.1016/j.tetlet.2007.06.170

M3 - Article

SN - 0040-4039

VL - 48

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 36

ER -

Microwave-assisted preparation of trifluoroacetaldehyde (fluoral): isolation and applications

Abstract

Scopus Subject Areas

Keywords

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