Microwave-Assisted Synthesis of Fine Chemicals – Triazoles

Microwave irradiation has been used as a prominent form of energy resource, shown to maximize efficiency by speeding up reactions. The microwave-assisted organic synthesis (MAOS) increases yields with shorter reaction times. Triazoles, one of the fine chemicals, is generally synthesized via “click chemistry” with azides and alkynes as starting materials. Through one step synthesis, it provides ease and accessibility to diverse libraries of compounds and improves atom economy. In particular, the microwave assisted click reaction provides one of the known reaction pathways to obtain biologically active triazoles in a short time compared to conventional methods. The reaction can result in 1,2,3-triazoles and 1,2,4-triazoles with high yields at the 1,4 or 1, 3- di-substituted positions. This chapter focuses on the recent advances (last decade) of this microwave assisted organic reactions resulting in triazoles.