Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones

Verona M. Outerbridge; Shainaz M. Landge; Hiroko Tamaki; Béla Török

Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones

Verona M. Outerbridge, Shainaz M. Landge, Hiroko Tamaki, Béla Török

Biochemistry, Chemistry, & Physics

University of Massachusetts Boston

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A one-pot, solid-acid-catalyzed, microwave-assisted synthesis of phthalazinones is described. The commercially available montmorillonite K-10 effectively catalyzed the condensation and substitution reactions. The approach was based on the direct cyclization of phthalaldehydic acid and opianic acid with substituted hydrazines. The reactions provided excellent yields and high selectivities in very short time (5-35 minutes).

Original language	American English
Journal	Synthesis
Volume	11
State	Published - 2009

Keywords

Phthalazinones
hydrazines
microwave heating
montmorillonite K-10
opianic acid
phthalaldehydic acid

DC Disciplines

Chemistry

Cite this

@article{24a140551c62494586ed4bc81200a8e7,

title = "Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones",

abstract = "A one-pot, solid-acid-catalyzed, microwave-assisted synthesis of phthalazinones is described. The commercially available montmorillonite K-10 effectively catalyzed the condensation and substitution reactions. The approach was based on the direct cyclization of phthalaldehydic acid and opianic acid with substituted hydrazines. The reactions provided excellent yields and high selectivities in very short time (5-35 minutes).",

keywords = "Phthalazinones, hydrazines, microwave heating, montmorillonite K-10, opianic acid, phthalaldehydic acid",

author = "Outerbridge, {Verona M.} and Landge, {Shainaz M.} and Hiroko Tamaki and B{\'e}la T{\"o}r{\"o}k",

note = "Verona M. Outerbridge, Shainaz M. Landge, Hiroko Tamaki, and B{\'e}la T{\"o}r{\"o}k. {"}Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones{"} Synthesis 11 (2009): 1801-1806. doi:10.1055/s-0028-1088074",

year = "2009",

language = "American English",

volume = "11",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

}

TY - JOUR

T1 - Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones

AU - Outerbridge, Verona M.

AU - Landge, Shainaz M.

AU - Tamaki, Hiroko

AU - Török, Béla

N1 - Verona M. Outerbridge, Shainaz M. Landge, Hiroko Tamaki, and Béla Török. "Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones" Synthesis 11 (2009): 1801-1806. doi:10.1055/s-0028-1088074

PY - 2009

Y1 - 2009

N2 - A one-pot, solid-acid-catalyzed, microwave-assisted synthesis of phthalazinones is described. The commercially available montmorillonite K-10 effectively catalyzed the condensation and substitution reactions. The approach was based on the direct cyclization of phthalaldehydic acid and opianic acid with substituted hydrazines. The reactions provided excellent yields and high selectivities in very short time (5-35 minutes).

AB - A one-pot, solid-acid-catalyzed, microwave-assisted synthesis of phthalazinones is described. The commercially available montmorillonite K-10 effectively catalyzed the condensation and substitution reactions. The approach was based on the direct cyclization of phthalaldehydic acid and opianic acid with substituted hydrazines. The reactions provided excellent yields and high selectivities in very short time (5-35 minutes).

KW - Phthalazinones

KW - hydrazines

KW - microwave heating

KW - montmorillonite K-10

KW - opianic acid

KW - phthalaldehydic acid

UR - http://dx.doi.org/10.1055/s-0028-1088074

M3 - Article

SN - 0039-7881

VL - 11

JO - Synthesis

JF - Synthesis

ER -

Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones

Abstract

Keywords

DC Disciplines

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