Molecular Physiology of Osmoregulation in Eels and Other Teleosts: The Role of Transporter Isoforms and Gene Duplication

Christopher P. Cutler, Gordon Cramb

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

This review focuses on recent developments in the molecular biology of ion and water transporter genes in fish and the potential role of their products in osmoregulation in both freshwater and seawater environments. In particular details of isoforms of various ATPases, co-transporters, exchangers and ion channels in the eel as well as other teleost species are described. Many of the teleost transporter isoforms discovered so far, appear to occur as twin or duplicate copies compared to their homologous counterparts in higher vertebrates, although these duplicate isoforms often have distinct tissue-specific and developmental stage-dependent expression patterns. The possible meaning of this information will be examined in relation to the fish genome duplication debate.
Original languageAmerican English
Pages (from-to)551-564
Number of pages14
JournalComparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology
Volume130
Issue number3
StatePublished - Oct 1 2001

Scopus Subject Areas

  • Biochemistry
  • Physiology
  • Molecular Biology

Keywords

  • Aquaporins
  • CFTR chloride ion channel
  • Cl/HCO exchanger
  • Genome duplication
  • Ion transport
  • Na,K-ATPase
  • Na/Cl cotransporter
  • Na/H exchanger
  • Na/HCO cotransporter
  • Na/K/2Cl cotransporter
  • V-type ATPase

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