Multicomponent Domino Cyclization- Oxidative Aromatization on a Bifunctional Pd/C/K -10 Catalyst: An Environmentally Benign Approach toward the Synthesis of Pyridines

Omar De Paolis, Jonathan Baffoe, Shainaz M. Landge, Béla Török

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61 Scopus citations

Abstract

A one-pot synthesis of substituted pyridines via a domino cyclization-oxidative aromatization (dehydrogenation) approach is described. The process is based on the use of a new bifunctional noble metal-solid acid catalyst, Pd/C/K-10 montmorillonite and microwave irradiation. The cyclization readily takes place on the strong solid acid while palladium dehydrogenates the dihydropyridine intermediates to the desired products.
Original languageAmerican English
JournalSynthesis
Volume21
StatePublished - 2008

Keywords

  • Pd/C/K-10 montmorillonite
  • bifunctional catalysis
  • green chemistry
  • microwave irradiation
  • pyridines
  • solid acid

DC Disciplines

  • Chemistry

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