Multicomponent domino cyclization-oxidative aromatization on a bifunctional Pd/C/K-10 catalyst: An environmentally benign approach toward the synthesis of pyridines

Omar De Paolis; Jonathan Baffoe; Shainaz M. Landge; Béla Török

doi:10.1055/s-0028-1083177

Multicomponent domino cyclization-oxidative aromatization on a bifunctional Pd/C/K-10 catalyst: An environmentally benign approach toward the synthesis of pyridines

Omar De Paolis
, Jonathan Baffoe
, Shainaz M. Landge
, Béla Török

Biochemistry, Chemistry & Physics

University of Massachusetts Boston

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

A one-pot synthesis of substituted pyridines via a domino cyclization-oxidative aromatization (dehydrogenation) approach is described. The process is based on the use of a new bifunctional noble metal-solid acid catalyst, Pd/C/K-10 montmorillonite and microwave irradiation. The cyclization readily takes place on the strong solid acid while palladium dehydrogenates the dihydropyridine intermediates to the desired products.

Original language	English
Article number	M02308SS
Pages (from-to)	3423-3428
Number of pages	6
Journal	Synthesis
Issue number	21
DOIs	https://doi.org/10.1055/s-0028-1083177
State	Published - Nov 3 2008

Scopus Subject Areas

Catalysis
Organic Chemistry

Keywords

Bifunctional catalysis
Green chemistry
Microwave irradiation
Pd/C/K-10 montmorillonite
Pyridines
Solid acid

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10.1055/s-0028-1083177

Cite this

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title = "Multicomponent domino cyclization-oxidative aromatization on a bifunctional Pd/C/K-10 catalyst: An environmentally benign approach toward the synthesis of pyridines",

abstract = "A one-pot synthesis of substituted pyridines via a domino cyclization-oxidative aromatization (dehydrogenation) approach is described. The process is based on the use of a new bifunctional noble metal-solid acid catalyst, Pd/C/K-10 montmorillonite and microwave irradiation. The cyclization readily takes place on the strong solid acid while palladium dehydrogenates the dihydropyridine intermediates to the desired products.",

keywords = "Bifunctional catalysis, Green chemistry, Microwave irradiation, Pd/C/K-10 montmorillonite, Pyridines, Solid acid",

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note = "Shainaz M. Landge, Omar De Paolis, Jonathan Baffoe, and B{\'e}la T{\"o}r{\"o}k. {"}Multicomponent Domino Cyclization- Oxidative Aromatization on a Bifunctional Pd/C/K -10 Catalyst: An Environmentally Benign Approach toward the Synthesis of Pyridines{"} Synthesis 21 (2008): 3423-3428. doi:10.1055/s-0028-1083177",

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doi = "10.1055/s-0028-1083177",

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T2 - An environmentally benign approach toward the synthesis of pyridines

AU - De Paolis, Omar

AU - Baffoe, Jonathan

AU - Landge, Shainaz M.

AU - Török, Béla

N1 - Shainaz M. Landge, Omar De Paolis, Jonathan Baffoe, and Béla Török. "Multicomponent Domino Cyclization- Oxidative Aromatization on a Bifunctional Pd/C/K -10 Catalyst: An Environmentally Benign Approach toward the Synthesis of Pyridines" Synthesis 21 (2008): 3423-3428. doi:10.1055/s-0028-1083177

PY - 2008/11/3

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N2 - A one-pot synthesis of substituted pyridines via a domino cyclization-oxidative aromatization (dehydrogenation) approach is described. The process is based on the use of a new bifunctional noble metal-solid acid catalyst, Pd/C/K-10 montmorillonite and microwave irradiation. The cyclization readily takes place on the strong solid acid while palladium dehydrogenates the dihydropyridine intermediates to the desired products.

AB - A one-pot synthesis of substituted pyridines via a domino cyclization-oxidative aromatization (dehydrogenation) approach is described. The process is based on the use of a new bifunctional noble metal-solid acid catalyst, Pd/C/K-10 montmorillonite and microwave irradiation. The cyclization readily takes place on the strong solid acid while palladium dehydrogenates the dihydropyridine intermediates to the desired products.

KW - Bifunctional catalysis

KW - Green chemistry

KW - Microwave irradiation

KW - Pd/C/K-10 montmorillonite

KW - Pyridines

KW - Solid acid

UR - https://www.scopus.com/pages/publications/56249115536

U2 - 10.1055/s-0028-1083177

DO - 10.1055/s-0028-1083177

M3 - Article

SN - 0039-7881

SP - 3423

EP - 3428

JO - Synthesis

JF - Synthesis

IS - 21

M1 - M02308SS

ER -

Multicomponent domino cyclization-oxidative aromatization on a bifunctional Pd/C/K-10 catalyst: An environmentally benign approach toward the synthesis of pyridines

Abstract

Scopus Subject Areas

Keywords

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