Noncoding RNA regulation of dopamine signaling in diseases of the central nervous system

William T. Carrick; Brandi Burks; Murray J. Cairns; Jannet Kocerha

doi:10.3389/fmolb.2016.00069

Noncoding RNA regulation of dopamine signaling in diseases of the central nervous system

William T. Carrick, Brandi Burks, Murray J. Cairns, Jannet Kocerha

Biochemistry, Chemistry, & Physics

Research output: Contribution to journal › Short survey › peer-review

17 Scopus citations

Abstract

Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic events provokes a multitude of neurological pathologies, including Parkinson's, schizophrenia, depression, and addiction. Growing evidence supports a key role for noncoding RNA (ncRNA) regulation in the synapse. This review will discuss the role of both short and long ncRNAs in dopamine signaling, including bioinformatic examination of the pathways they target. Specifically, we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease.

Original language	English
Article number	69
Journal	Frontiers in Molecular Biosciences
Volume	3
Issue number	OCT
DOIs	https://doi.org/10.3389/fmolb.2016.00069
State	Published - Oct 25 2016

Keywords

Dopamine
Dopaminergic
Epigenetic
MicroRNAs
Neurodegeneration
Noncoding RNA
Psychiatric
Schizophrenia

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title = "Noncoding RNA regulation of dopamine signaling in diseases of the central nervous system",

abstract = "Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic events provokes a multitude of neurological pathologies, including Parkinson's, schizophrenia, depression, and addiction. Growing evidence supports a key role for noncoding RNA (ncRNA) regulation in the synapse. This review will discuss the role of both short and long ncRNAs in dopamine signaling, including bioinformatic examination of the pathways they target. Specifically, we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease.",

keywords = "Dopamine, Dopaminergic, Epigenetic, MicroRNAs, Neurodegeneration, Noncoding RNA, Psychiatric, Schizophrenia",

author = "Carrick, {William T.} and Brandi Burks and Cairns, {Murray J.} and Jannet Kocerha",

note = "Publisher Copyright: {\textcopyright} 2016 Carrick, Burks, Cairns and Kocerha.",

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AU - Carrick, William T.

AU - Burks, Brandi

AU - Cairns, Murray J.

AU - Kocerha, Jannet

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N2 - Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic events provokes a multitude of neurological pathologies, including Parkinson's, schizophrenia, depression, and addiction. Growing evidence supports a key role for noncoding RNA (ncRNA) regulation in the synapse. This review will discuss the role of both short and long ncRNAs in dopamine signaling, including bioinformatic examination of the pathways they target. Specifically, we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease.

AB - Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic events provokes a multitude of neurological pathologies, including Parkinson's, schizophrenia, depression, and addiction. Growing evidence supports a key role for noncoding RNA (ncRNA) regulation in the synapse. This review will discuss the role of both short and long ncRNAs in dopamine signaling, including bioinformatic examination of the pathways they target. Specifically, we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease.

KW - Dopamine

KW - Dopaminergic

KW - Epigenetic

KW - MicroRNAs

KW - Neurodegeneration

KW - Noncoding RNA

KW - Psychiatric

KW - Schizophrenia

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DO - 10.3389/fmolb.2016.00069

M3 - Short survey

AN - SCOPUS:85026419830

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VL - 3

JO - Frontiers in Molecular Biosciences

JF - Frontiers in Molecular Biosciences

IS - OCT

M1 - 69

ER -

Noncoding RNA regulation of dopamine signaling in diseases of the central nervous system

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Keywords

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