Organic Synthesis with Amino Acid Dehydrogenases, Transaminases, Amine Oxidases, and Amine Dehydrogenases

Samantha K. Au; Jonathan Groover; Brent D. Feske; Andreas S. Bommarius

doi:10.1016/B978-0-12-411518-7.00007-X

Organic Synthesis with Amino Acid Dehydrogenases, Transaminases, Amine Oxidases, and Amine Dehydrogenases

Samantha K. Au, Jonathan Groover, Brent D. Feske, Andreas S. Bommarius

Biochemistry, Chemistry, & Physics

Research output: Contribution to book or proceeding › Chapter › peer-review

8 Scopus citations

Abstract

This chapter describes various enzyme-catalyzed reactions for production of amino acids and chiral amines. Enantiomerically pure amino acids can be produced from keto acids via amino acid dehydrogenase (AADH) and transaminase (TA). Enantiomerically pure amines are available from prochiral ketones via catalysis with TA, amine oxidase (AO), and amine dehydrogenase (AmDH) enzymes.

Original language	English
Title of host publication	Organic Synthesis Using Biocatalysis
Publisher	Elsevier Inc.
Pages	187-212
Number of pages	26
ISBN (Electronic)	9780124115422
ISBN (Print)	9780124115187
DOIs	https://doi.org/10.1016/B978-0-12-411518-7.00007-X
State	Published - 2016

Keywords

Amine dehydrogenase
Amino acid dehydrogenase
Chemoenzymatic synthesis
Chiral amine
Transaminase

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10.1016/B978-0-12-411518-7.00007-X

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title = "Organic Synthesis with Amino Acid Dehydrogenases, Transaminases, Amine Oxidases, and Amine Dehydrogenases",

abstract = "This chapter describes various enzyme-catalyzed reactions for production of amino acids and chiral amines. Enantiomerically pure amino acids can be produced from keto acids via amino acid dehydrogenase (AADH) and transaminase (TA). Enantiomerically pure amines are available from prochiral ketones via catalysis with TA, amine oxidase (AO), and amine dehydrogenase (AmDH) enzymes.",

keywords = "Amine dehydrogenase, Amino acid dehydrogenase, Chemoenzymatic synthesis, Chiral amine, Transaminase",

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T1 - Organic Synthesis with Amino Acid Dehydrogenases, Transaminases, Amine Oxidases, and Amine Dehydrogenases

AU - Au, Samantha K.

AU - Groover, Jonathan

AU - Feske, Brent D.

AU - Bommarius, Andreas S.

PY - 2016

Y1 - 2016

N2 - This chapter describes various enzyme-catalyzed reactions for production of amino acids and chiral amines. Enantiomerically pure amino acids can be produced from keto acids via amino acid dehydrogenase (AADH) and transaminase (TA). Enantiomerically pure amines are available from prochiral ketones via catalysis with TA, amine oxidase (AO), and amine dehydrogenase (AmDH) enzymes.

AB - This chapter describes various enzyme-catalyzed reactions for production of amino acids and chiral amines. Enantiomerically pure amino acids can be produced from keto acids via amino acid dehydrogenase (AADH) and transaminase (TA). Enantiomerically pure amines are available from prochiral ketones via catalysis with TA, amine oxidase (AO), and amine dehydrogenase (AmDH) enzymes.

KW - Amine dehydrogenase

KW - Amino acid dehydrogenase

KW - Chemoenzymatic synthesis

KW - Chiral amine

KW - Transaminase

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U2 - 10.1016/B978-0-12-411518-7.00007-X

DO - 10.1016/B978-0-12-411518-7.00007-X

M3 - Chapter

AN - SCOPUS:84967194747

SN - 9780124115187

SP - 187

EP - 212

BT - Organic Synthesis Using Biocatalysis

PB - Elsevier Inc.

ER -

Organic Synthesis with Amino Acid Dehydrogenases, Transaminases, Amine Oxidases, and Amine Dehydrogenases

Abstract

Keywords

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