Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study

Virginia Engels Calvo; Sara Cruz Melguizo; Alejandra Abascal-Saiz; Laura Forcén Acebal; Amalia Sánchez-Migallón; Pilar Pintado Recarte; Celia Cuenca Marín; Beatriz Marcos Puig; Pablo G. Del Barrio Fernández; Olga Nieto Velasco; María Luisa de la Cruz Conty; Oscar Martínez-Perez; María Belén Garrido Luque; Camino Fernández Fernández; Ana Villalba Yarza; Esther María Canedo Carballeira; María Begoña Dueñas Carazo; Rosario Redondo Aguilar; Ángeles Sánchez-Vegazo García; Esther Álvarez Silvares; María Isabel Pardo Pumar; Macarena Alférez Álvarez-Mallo; Víctor Muñoz Carmona; Noelia Pérez Pérez; Cristina Álvarez Colomo; Onofre Alomar Mateu; Claudio Marañon Di Leo; María del Carmen Parada Millán; Adrián Martín García; José Navarrina Martínez; Anna Mundó Fornell; Elena Pascual Salvador; Tania Manrique Gómez; Marta Ruth Meca Casbas; Noemí Freixas Grimalt; Adriana Aquise; María del Mar Gil; Eduardo Cazorla Amorós; Alberto Armijo Sánchez; María Isabel Conca Rodero; Ana Belén Oreja Cuesta; Cristina Ruiz Aguilar; Susana Fernández García; Mercedes Ramírez Gómez; Esther Vanessa Aguilar Galán; Rocío López Pérez; Carmen Baena Luque; Luz María Jiménez Losa; Susana Soldevilla Pérez; María Reyes Granell Escobar

doi:10.1016/j.fertnstert.2021.04.005

Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study

Virginia Engels Calvo, Sara Cruz Melguizo, Alejandra Abascal-Saiz, Laura Forcén Acebal, Amalia Sánchez-Migallón, Pilar Pintado Recarte, Celia Cuenca Marín, Beatriz Marcos Puig, Pablo G. Del Barrio Fernández, Olga Nieto Velasco, María Luisa de la Cruz Conty, Oscar Martínez-Perez, María Belén Garrido Luque, Camino Fernández Fernández, Ana Villalba Yarza, Esther María Canedo Carballeira, María Begoña Dueñas Carazo, Rosario Redondo Aguilar, Ángeles Sánchez-Vegazo García, Esther Álvarez SilvaresMaría Isabel Pardo Pumar, Macarena Alférez Álvarez-Mallo, Víctor Muñoz Carmona, Noelia Pérez Pérez, Cristina Álvarez Colomo, Onofre Alomar Mateu, Claudio Marañon Di Leo, María del Carmen Parada Millán, Adrián Martín García, José Navarrina Martínez, Anna Mundó Fornell, Elena Pascual Salvador, Tania Manrique Gómez, Marta Ruth Meca Casbas, Noemí Freixas Grimalt, Adriana Aquise, María del Mar Gil, Eduardo Cazorla Amorós, Alberto Armijo Sánchez, María Isabel Conca Rodero, Ana Belén Oreja Cuesta, Cristina Ruiz Aguilar, Susana Fernández García, Mercedes Ramírez Gómez, Esther Vanessa Aguilar Galán, Rocío López Pérez, Carmen Baena Luque, Luz María Jiménez Losa, Susana Soldevilla Pérez, María Reyes Granell Escobar

Biochemistry, Chemistry & Physics

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Objective: To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes). Design: Multicenter, prospective, observational study. Setting: 78 centers participating in the Spanish COVID19 Registry. Patient(s): 1,347 pregnant women with SARS-CoV-2 positive results registered consecutively between February 26 and November 5, 2020. Intervention(s): The patients’ information was collected from their medical records, and multivariable regression analyses were performed, controlling for maternal age and the clinical presentation of the infection. Main Outcome Measure(s): Obstetrics and neonatal outcomes, pregnancy comorbidities, intensive care unit admission, mechanical ventilation need, and medical conditions. Result(s): The IVF group included 74 (5.5%) women whereas the spontaneous pregnancy group included 1,275 (94.5%) women. The operative delivery rate was high in all patients, especially in the IVF group, where cesarean section became the most frequent method of delivery (55.4%, compared with 26.1% of the spontaneous pregnancy group). The reason for cesarean section was induction failure in 56.1% of the IVF patients. IVF women had more gestational hypertensive disorders (16.2% vs. 4.5% among spontaneous pregnancy women, adjusted odds ratio [aOR] 5.31, 95% confidence interval [CI] 2.45–10.93) irrespective of oocyte origin. The higher rate of intensive care unit admittance observed in the IVF group (8.1% vs. 2.4% in the spontaneous pregnancy group) was attributed to preeclampsia (aOR 11.82, 95% CI 5.25–25.87), not to the type of conception. Conclusion(s): A high rate of operative delivery was observed in pregnant women infected with SARS-CoV-2, especially in those with IVF pregnancies; method of conception did not affect fetal or maternal outcomes, except for preeclampsia. Clinical Trial Registration Number: NCT04558996.

Original language	English
Pages (from-to)	731-740
Number of pages	10
Journal	Fertility and Sterility
Volume	116
Issue number	3
DOIs	https://doi.org/10.1016/j.fertnstert.2021.04.005
State	Published - Sep 2021

Scopus Subject Areas

Reproductive Medicine
Obstetrics and Gynecology

Keywords

COVID-19
assisted reproduction
cohort study
intensive care unit
pregnancy

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10.1016/j.fertnstert.2021.04.005

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Engels Calvo, V., Cruz Melguizo, S., Abascal-Saiz, A., Forcén Acebal, L., Sánchez-Migallón, A., Pintado Recarte, P., Cuenca Marín, C., Marcos Puig, B., Del Barrio Fernández, P. G., Nieto Velasco, O., de la Cruz Conty, M. L., Martínez-Perez, O., Garrido Luque, M. B., Fernández, C. F., Yarza, A. V., Canedo Carballeira, E. M., Dueñas Carazo, M. B., Aguilar, R. R., Sánchez-Vegazo García, Á., ... Granell Escobar, M. R. (2021). Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study. Fertility and Sterility, 116(3), 731-740. https://doi.org/10.1016/j.fertnstert.2021.04.005

@article{5039af409011453da15ea44d976b2098,

title = "Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study",

abstract = "Objective: To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes). Design: Multicenter, prospective, observational study. Setting: 78 centers participating in the Spanish COVID19 Registry. Patient(s): 1,347 pregnant women with SARS-CoV-2 positive results registered consecutively between February 26 and November 5, 2020. Intervention(s): The patients{\textquoteright} information was collected from their medical records, and multivariable regression analyses were performed, controlling for maternal age and the clinical presentation of the infection. Main Outcome Measure(s): Obstetrics and neonatal outcomes, pregnancy comorbidities, intensive care unit admission, mechanical ventilation need, and medical conditions. Result(s): The IVF group included 74 (5.5%) women whereas the spontaneous pregnancy group included 1,275 (94.5%) women. The operative delivery rate was high in all patients, especially in the IVF group, where cesarean section became the most frequent method of delivery (55.4%, compared with 26.1% of the spontaneous pregnancy group). The reason for cesarean section was induction failure in 56.1% of the IVF patients. IVF women had more gestational hypertensive disorders (16.2% vs. 4.5% among spontaneous pregnancy women, adjusted odds ratio [aOR] 5.31, 95% confidence interval [CI] 2.45–10.93) irrespective of oocyte origin. The higher rate of intensive care unit admittance observed in the IVF group (8.1% vs. 2.4% in the spontaneous pregnancy group) was attributed to preeclampsia (aOR 11.82, 95% CI 5.25–25.87), not to the type of conception. Conclusion(s): A high rate of operative delivery was observed in pregnant women infected with SARS-CoV-2, especially in those with IVF pregnancies; method of conception did not affect fetal or maternal outcomes, except for preeclampsia. Clinical Trial Registration Number: NCT04558996.",

keywords = "COVID-19, assisted reproduction, cohort study, intensive care unit, pregnancy",

author = "{Engels Calvo}, Virginia and {Cruz Melguizo}, Sara and Alejandra Abascal-Saiz and {Forc{\'e}n Acebal}, Laura and Amalia S{\'a}nchez-Migall{\'o}n and {Pintado Recarte}, Pilar and {Cuenca Mar{\'i}n}, Celia and {Marcos Puig}, Beatriz and {Del Barrio Fern{\'a}ndez}, {Pablo G.} and {Nieto Velasco}, Olga and {de la Cruz Conty}, {Mar{\'i}a Luisa} and Oscar Mart{\'i}nez-Perez and {Garrido Luque}, {Mar{\'i}a Bel{\'e}n} and Fern{\'a}ndez, {Camino Fern{\'a}ndez} and Yarza, {Ana Villalba} and {Canedo Carballeira}, {Esther Mar{\'i}a} and {Due{\~n}as Carazo}, {Mar{\'i}a Bego{\~n}a} and Aguilar, {Rosario Redondo} and {S{\'a}nchez-Vegazo Garc{\'i}a}, {\'A}ngeles and Silvares, {Esther {\'A}lvarez} and {Pardo Pumar}, {Mar{\'i}a Isabel} and {\'A}lvarez-Mallo, {Macarena Alf{\'e}rez} and Carmona, {V{\'i}ctor Mu{\~n}oz} and P{\'e}rez, {Noelia P{\'e}rez} and Colomo, {Cristina {\'A}lvarez} and Mateu, {Onofre Alomar} and {Di Leo}, {Claudio Mara{\~n}on} and Mill{\'a}n, {Mar{\'i}a del Carmen Parada} and Garc{\'i}a, {Adri{\'a}n Mart{\'i}n} and Mart{\'i}nez, {Jos{\'e} Navarrina} and Fornell, {Anna Mund{\'o}} and Salvador, {Elena Pascual} and G{\'o}mez, {Tania Manrique} and {Meca Casbas}, {Marta Ruth} and Grimalt, {Noem{\'i} Freixas} and Adriana Aquise and Gil, {Mar{\'i}a del Mar} and Amor{\'o}s, {Eduardo Cazorla} and S{\'a}nchez, {Alberto Armijo} and {Conca Rodero}, {Mar{\'i}a Isabel} and {Oreja Cuesta}, {Ana Bel{\'e}n} and Aguilar, {Cristina Ruiz} and Garc{\'i}a, {Susana Fern{\'a}ndez} and G{\'o}mez, {Mercedes Ram{\'i}rez} and {Aguilar Gal{\'a}n}, {Esther Vanessa} and P{\'e}rez, {Roc{\'i}o L{\'o}pez} and Luque, {Carmen Baena} and {Jim{\'e}nez Losa}, {Luz Mar{\'i}a} and P{\'e}rez, {Susana Soldevilla} and {Granell Escobar}, {Mar{\'i}a Reyes}",

note = "Publisher Copyright: {\textcopyright} 2021 American Society for Reproductive Medicine",

year = "2021",

month = sep,

doi = "10.1016/j.fertnstert.2021.04.005",

language = "English",

volume = "116",

pages = "731--740",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "3",

}

Engels Calvo, V, Cruz Melguizo, S, Abascal-Saiz, A, Forcén Acebal, L, Sánchez-Migallón, A, Pintado Recarte, P, Cuenca Marín, C, Marcos Puig, B, Del Barrio Fernández, PG, Nieto Velasco, O, de la Cruz Conty, ML, Martínez-Perez, O, Garrido Luque, MB, Fernández, CF, Yarza, AV, Canedo Carballeira, EM, Dueñas Carazo, MB, Aguilar, RR, Sánchez-Vegazo García, Á, Silvares, EÁ, Pardo Pumar, MI, Álvarez-Mallo, MA, Carmona, VM, Pérez, NP, Colomo, CÁ, Mateu, OA, Di Leo, CM, Millán, MDCP, García, AM, Martínez, JN, Fornell, AM, Salvador, EP, Gómez, TM, Meca Casbas, MR, Grimalt, NF, Aquise, A, Gil, MDM, Amorós, EC, Sánchez, AA, Conca Rodero, MI, Oreja Cuesta, AB, Aguilar, CR, García, SF, Gómez, MR, Aguilar Galán, EV, Pérez, RL, Luque, CB, Jiménez Losa, LM, Pérez, SS & Granell Escobar, MR 2021, 'Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study', Fertility and Sterility, vol. 116, no. 3, pp. 731-740. https://doi.org/10.1016/j.fertnstert.2021.04.005

TY - JOUR

T1 - Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women

T2 - a prospective observational study

AU - Engels Calvo, Virginia

AU - Cruz Melguizo, Sara

AU - Abascal-Saiz, Alejandra

AU - Forcén Acebal, Laura

AU - Sánchez-Migallón, Amalia

AU - Pintado Recarte, Pilar

AU - Cuenca Marín, Celia

AU - Marcos Puig, Beatriz

AU - Del Barrio Fernández, Pablo G.

AU - Nieto Velasco, Olga

AU - de la Cruz Conty, María Luisa

AU - Martínez-Perez, Oscar

AU - Garrido Luque, María Belén

AU - Fernández, Camino Fernández

AU - Yarza, Ana Villalba

AU - Canedo Carballeira, Esther María

AU - Dueñas Carazo, María Begoña

AU - Aguilar, Rosario Redondo

AU - Sánchez-Vegazo García, Ángeles

AU - Silvares, Esther Álvarez

AU - Pardo Pumar, María Isabel

AU - Álvarez-Mallo, Macarena Alférez

AU - Carmona, Víctor Muñoz

AU - Pérez, Noelia Pérez

AU - Colomo, Cristina Álvarez

AU - Mateu, Onofre Alomar

AU - Di Leo, Claudio Marañon

AU - Millán, María del Carmen Parada

AU - García, Adrián Martín

AU - Martínez, José Navarrina

AU - Fornell, Anna Mundó

AU - Salvador, Elena Pascual

AU - Gómez, Tania Manrique

AU - Meca Casbas, Marta Ruth

AU - Grimalt, Noemí Freixas

AU - Aquise, Adriana

AU - Gil, María del Mar

AU - Amorós, Eduardo Cazorla

AU - Sánchez, Alberto Armijo

AU - Conca Rodero, María Isabel

AU - Oreja Cuesta, Ana Belén

AU - Aguilar, Cristina Ruiz

AU - García, Susana Fernández

AU - Gómez, Mercedes Ramírez

AU - Aguilar Galán, Esther Vanessa

AU - Pérez, Rocío López

AU - Luque, Carmen Baena

AU - Jiménez Losa, Luz María

AU - Pérez, Susana Soldevilla

AU - Granell Escobar, María Reyes

PY - 2021/9

Y1 - 2021/9

N2 - Objective: To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes). Design: Multicenter, prospective, observational study. Setting: 78 centers participating in the Spanish COVID19 Registry. Patient(s): 1,347 pregnant women with SARS-CoV-2 positive results registered consecutively between February 26 and November 5, 2020. Intervention(s): The patients’ information was collected from their medical records, and multivariable regression analyses were performed, controlling for maternal age and the clinical presentation of the infection. Main Outcome Measure(s): Obstetrics and neonatal outcomes, pregnancy comorbidities, intensive care unit admission, mechanical ventilation need, and medical conditions. Result(s): The IVF group included 74 (5.5%) women whereas the spontaneous pregnancy group included 1,275 (94.5%) women. The operative delivery rate was high in all patients, especially in the IVF group, where cesarean section became the most frequent method of delivery (55.4%, compared with 26.1% of the spontaneous pregnancy group). The reason for cesarean section was induction failure in 56.1% of the IVF patients. IVF women had more gestational hypertensive disorders (16.2% vs. 4.5% among spontaneous pregnancy women, adjusted odds ratio [aOR] 5.31, 95% confidence interval [CI] 2.45–10.93) irrespective of oocyte origin. The higher rate of intensive care unit admittance observed in the IVF group (8.1% vs. 2.4% in the spontaneous pregnancy group) was attributed to preeclampsia (aOR 11.82, 95% CI 5.25–25.87), not to the type of conception. Conclusion(s): A high rate of operative delivery was observed in pregnant women infected with SARS-CoV-2, especially in those with IVF pregnancies; method of conception did not affect fetal or maternal outcomes, except for preeclampsia. Clinical Trial Registration Number: NCT04558996.

AB - Objective: To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes). Design: Multicenter, prospective, observational study. Setting: 78 centers participating in the Spanish COVID19 Registry. Patient(s): 1,347 pregnant women with SARS-CoV-2 positive results registered consecutively between February 26 and November 5, 2020. Intervention(s): The patients’ information was collected from their medical records, and multivariable regression analyses were performed, controlling for maternal age and the clinical presentation of the infection. Main Outcome Measure(s): Obstetrics and neonatal outcomes, pregnancy comorbidities, intensive care unit admission, mechanical ventilation need, and medical conditions. Result(s): The IVF group included 74 (5.5%) women whereas the spontaneous pregnancy group included 1,275 (94.5%) women. The operative delivery rate was high in all patients, especially in the IVF group, where cesarean section became the most frequent method of delivery (55.4%, compared with 26.1% of the spontaneous pregnancy group). The reason for cesarean section was induction failure in 56.1% of the IVF patients. IVF women had more gestational hypertensive disorders (16.2% vs. 4.5% among spontaneous pregnancy women, adjusted odds ratio [aOR] 5.31, 95% confidence interval [CI] 2.45–10.93) irrespective of oocyte origin. The higher rate of intensive care unit admittance observed in the IVF group (8.1% vs. 2.4% in the spontaneous pregnancy group) was attributed to preeclampsia (aOR 11.82, 95% CI 5.25–25.87), not to the type of conception. Conclusion(s): A high rate of operative delivery was observed in pregnant women infected with SARS-CoV-2, especially in those with IVF pregnancies; method of conception did not affect fetal or maternal outcomes, except for preeclampsia. Clinical Trial Registration Number: NCT04558996.

KW - COVID-19

KW - assisted reproduction

KW - cohort study

KW - intensive care unit

KW - pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85105440708&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2021.04.005

DO - 10.1016/j.fertnstert.2021.04.005

M3 - Article

C2 - 33972083

AN - SCOPUS:85105440708

SN - 0015-0282

VL - 116

SP - 731

EP - 740

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 3

ER -

Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study

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