Post-Test Diagnostic Accuracy Measures of a Continuous Test With a Disease of Ordinal Multistages

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Abstract

Positive predicted value and negative predicted value are used by clinicians to evaluate how likely a disease stage is present given the test results. In contrast, positive and negative likelihood ratios (LRs) are used in practice to assess the potential utility of a specific diagnostic test and the likelihood of a patient having the condition. This article introduces the concepts and the derivation of generalized predictive values and LRs from binary diseases to ordinal multistages diseases. We evaluate the performance of the proposed methods with numerical examples. We illustrated the proposed methods provided using real data.

Original languageEnglish
Pages (from-to)552-558
Number of pages7
JournalStatistics in Biopharmaceutical Research
Volume14
Issue number4
DOIs
StatePublished - 2022

Keywords

  • Alzheimer’s disease
  • Negative predictive value likelihood ratios
  • Ordinal disease stage
  • Positive predictive value

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