Relationship between Vascular and Physical Function in Individuals with Peripheral Neuropathy

Background: Peripheral neuropathy is characterized by a reduction/alteration in sensation, muscle weakness and chronic fatigue, which may compromise physical function. Mechanisms contributing to the development of PN may include poor vascular function. The purpose was to examine the relationship between measures of vascular and physical function in individuals with peripheral neuropathy.

Methods: This study used a cross sectional design to examine 59 individuals with peripheral neuropathy. Strain gauge plethysmography was used to assess lower leg vascular function. Specific measures included resting in-flow, venous outflow (VOt1/2), and reactive hyperemic blood flow (RHBF). Physical function was examined using a 6-minute walk (6MWD), the timed up and go (TUG) test, and isokinetic knee extension (KE) and flexion (KF). Results: RHBF was related to the TUG (r=-0.31, p=0.02) and 6MWD (r=0.37, p=0.007). Patients in the top tertile of the TUG had significantly higher peak RHBF compared to the lower tertiles. Those who walked 400m on the 6MWD had lower RHBF compared to those who walked >400m. Finally, those in the top tertile of KF exhibited faster VOt1/2.

Conclusions: These data indicate a relationship between vascular and physical function in peripheral neuropathy. Individuals with greater physical function exhibit more favorable measures of arterial inflow and venous outflow.