Solvent-Free Acid-Catalyzed Electrophilic Annelations: A New Green Approach for the Synthesis of Substituted Five-Membered N-Heterocycles

Abid Shaikh; Andrew Spaeth; Béla Török

Solvent-Free Acid-Catalyzed Electrophilic Annelations: A New Green Approach for the Synthesis of Substituted Five-Membered N-Heterocycles

Abid Shaikh, Andrew Spaeth, Béla Török

Biochemistry, Chemistry, & Physics

Research output: Contribution to journal › Article › peer-review

Abstract

An effective microwave-induced, solid acid-catalyzed, environmentally benign synthesis of substituted pyrroles, indoles and carbazoles under solvent-free conditions is described. The new synthetic methodology is based on the use of a considerably strong solid acid, K-10 montmorillonite. Both the cyclialkylation of amines and annelation of pyrroles and indoles have been completed within minutes and provided excellent (75–98 %) yields with practically 100 % selectivity.

Original language	American English
Journal	Advanced Synthesis and Catalysis
Volume	348
State	Published - 2006

Keywords

Carbazoles
Indoles
K-10 montmorillonite
Microwave heating
Pyrroles
Solid acids

DC Disciplines

Chemistry

Cite this

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title = "Solvent-Free Acid-Catalyzed Electrophilic Annelations: A New Green Approach for the Synthesis of Substituted Five-Membered N-Heterocycles",

abstract = "An effective microwave-induced, solid acid-catalyzed, environmentally benign synthesis of substituted pyrroles, indoles and carbazoles under solvent-free conditions is described. The new synthetic methodology is based on the use of a considerably strong solid acid, K-10 montmorillonite. Both the cyclialkylation of amines and annelation of pyrroles and indoles have been completed within minutes and provided excellent (75–98 %) yields with practically 100 % selectivity.",

keywords = "Carbazoles, Indoles, K-10 montmorillonite, Microwave heating, Pyrroles, Solid acids",

author = "Abid Shaikh and Andrew Spaeth and B{\'e}la T{\"o}r{\"o}k",

year = "2006",

language = "American English",

volume = "348",

journal = "Advanced Synthesis and Catalysis",

issn = "1615-4150",

publisher = "Wiley-VCH Verlag",

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TY - JOUR

T1 - Solvent-Free Acid-Catalyzed Electrophilic Annelations: A New Green Approach for the Synthesis of Substituted Five-Membered N-Heterocycles

AU - Shaikh, Abid

AU - Spaeth, Andrew

AU - Török, Béla

PY - 2006

Y1 - 2006

N2 - An effective microwave-induced, solid acid-catalyzed, environmentally benign synthesis of substituted pyrroles, indoles and carbazoles under solvent-free conditions is described. The new synthetic methodology is based on the use of a considerably strong solid acid, K-10 montmorillonite. Both the cyclialkylation of amines and annelation of pyrroles and indoles have been completed within minutes and provided excellent (75–98 %) yields with practically 100 % selectivity.

AB - An effective microwave-induced, solid acid-catalyzed, environmentally benign synthesis of substituted pyrroles, indoles and carbazoles under solvent-free conditions is described. The new synthetic methodology is based on the use of a considerably strong solid acid, K-10 montmorillonite. Both the cyclialkylation of amines and annelation of pyrroles and indoles have been completed within minutes and provided excellent (75–98 %) yields with practically 100 % selectivity.

KW - Carbazoles

KW - Indoles

KW - K-10 montmorillonite

KW - Microwave heating

KW - Pyrroles

KW - Solid acids

UR - http://dx.doi.org/10.1002/adsc.200606200

M3 - Article

SN - 1615-4150

VL - 348

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

ER -

Solvent-Free Acid-Catalyzed Electrophilic Annelations: A New Green Approach for the Synthesis of Substituted Five-Membered N-Heterocycles

Abstract

Keywords

DC Disciplines

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