Submicron Surface Plasmon Biosensors for Glucose Concentration Assessment

Susan B. Klein; Nazanin Mosavian; John Jenkins; Jonathan D. Vo; Dragos Amarie; James A. Glazier

Submicron Surface Plasmon Biosensors for Glucose Concentration Assessment

Susan B. Klein, Nazanin Mosavian, John Jenkins, Jonathan D. Vo, Dragos Amarie, James A. Glazier

Biochemistry, Chemistry, & Physics

Research output: Contribution to conference › Presentation

Abstract

<p> The construction of a miniature surface plasmon sensor utilizing stationary beads supporting a submicron spherical metal shell was achieved. A small aperture at the base admits visible light that excites a surface-plasmon-resonance within the metallic shell. The micron surface-plasmon-resonance sensor (MSPRS) is sensitive to the surface binding of biomolecules through alterations of the angle of reflection and the spheres can be used to visualize conformational changes in the bound biomolecules, for example as the oxidation state changes. D-glucose and L-glucose were tested to verify the anticipated alterations in radiant light, L&hyphen;glucose being an inactive control. Diffusive biomolecules play key roles in the embryonic development, immune system response, wound healing, tissue homeostasis, and diseases such as cancer. This work seeks to monitor molecular diversity and concentration. The MSPRS enables the measurement of the bound molecules with accuracy not possible with planar sensors.</p>

Original language	American English
State	Published - Jan 1 2016
Event	International Conference on Medical Physics and Biomedical Engineering - Duration: Jan 1 2016 → …

Conference

Conference	International Conference on Medical Physics and Biomedical Engineering
Period	01/1/16 → …

Keywords

Glucose concentration assessment
Submicron surface plasmon biosensors

DC Disciplines

Physics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Submicron Surface Plasmon Biosensors for Glucose Concentration Assessment",

abstract = " The construction of a miniature surface plasmon sensor utilizing stationary beads supporting a submicron spherical metal shell was achieved. A small aperture at the base admits visible light that excites a surface-plasmon-resonance within the metallic shell. The micron surface-plasmon-resonance sensor (MSPRS) is sensitive to the surface binding of biomolecules through alterations of the angle of reflection and the spheres can be used to visualize conformational changes in the bound biomolecules, for example as the oxidation state changes. D-glucose and L-glucose were tested to verify the anticipated alterations in radiant light, L&hyphen;glucose being an inactive control. Diffusive biomolecules play key roles in the embryonic development, immune system response, wound healing, tissue homeostasis, and diseases such as cancer. This work seeks to monitor molecular diversity and concentration. The MSPRS enables the measurement of the bound molecules with accuracy not possible with planar sensors.",

keywords = "Glucose concentration assessment, Submicron surface plasmon biosensors",

author = "Klein, {Susan B.} and Nazanin Mosavian and John Jenkins and Vo, {Jonathan D.} and Dragos Amarie and Glazier, {James A.}",

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language = "American English",

note = "International Conference on Medical Physics and Biomedical Engineering ; Conference date: 01-01-2016",

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TY - CONF

T1 - Submicron Surface Plasmon Biosensors for Glucose Concentration Assessment

AU - Klein, Susan B.

AU - Mosavian, Nazanin

AU - Jenkins, John

AU - Vo, Jonathan D.

AU - Amarie, Dragos

AU - Glazier, James A.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The construction of a miniature surface plasmon sensor utilizing stationary beads supporting a submicron spherical metal shell was achieved. A small aperture at the base admits visible light that excites a surface-plasmon-resonance within the metallic shell. The micron surface-plasmon-resonance sensor (MSPRS) is sensitive to the surface binding of biomolecules through alterations of the angle of reflection and the spheres can be used to visualize conformational changes in the bound biomolecules, for example as the oxidation state changes. D-glucose and L-glucose were tested to verify the anticipated alterations in radiant light, L&hyphen;glucose being an inactive control. Diffusive biomolecules play key roles in the embryonic development, immune system response, wound healing, tissue homeostasis, and diseases such as cancer. This work seeks to monitor molecular diversity and concentration. The MSPRS enables the measurement of the bound molecules with accuracy not possible with planar sensors.

AB - The construction of a miniature surface plasmon sensor utilizing stationary beads supporting a submicron spherical metal shell was achieved. A small aperture at the base admits visible light that excites a surface-plasmon-resonance within the metallic shell. The micron surface-plasmon-resonance sensor (MSPRS) is sensitive to the surface binding of biomolecules through alterations of the angle of reflection and the spheres can be used to visualize conformational changes in the bound biomolecules, for example as the oxidation state changes. D-glucose and L-glucose were tested to verify the anticipated alterations in radiant light, L&hyphen;glucose being an inactive control. Diffusive biomolecules play key roles in the embryonic development, immune system response, wound healing, tissue homeostasis, and diseases such as cancer. This work seeks to monitor molecular diversity and concentration. The MSPRS enables the measurement of the bound molecules with accuracy not possible with planar sensors.

KW - Glucose concentration assessment

KW - Submicron surface plasmon biosensors

UR - https://digitalcommons.georgiasouthern.edu/physics-facpres/7

M3 - Presentation

T2 - International Conference on Medical Physics and Biomedical Engineering

Y2 - 1 January 2016

ER -

Submicron Surface Plasmon Biosensors for Glucose Concentration Assessment

Abstract

Conference

Keywords

DC Disciplines

UN SDGs

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