TY - JOUR
T1 - Synthesis, Characterization, Computational Study, and Biological Relevance of a Family of Isostructural, Mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) Complexes Containing Pyridoxine, an Essential Ingredient of Vitamin B6 Enzyme
AU - Stouder, Caitlyn E.
AU - Warren, Khairi J.
AU - Perdue, Olivia F.
AU - Stewart, Amanda L.
AU - Padgett, Clifford W.
AU - Amonette, Allison J.
AU - Saha, Arpita
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - The synthesis and characterization of a family of LnIII complexes (Ln = Gd(1), Tb(2), Dy(3), Ho(4) and Er(5)) of formula [(LnIII(NO3)2(OH2)(pyridoxine)2](NO3) are reported, where pyridoxine is 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine. They were obtained from the reaction of Ln(NO3)3 with pyridoxine in ethanol in a 1:1 M ratio. The crystal structures of representative 1 and 5 were obtained using a single-crystal X-ray diffractometer. The subsequent characterization of all the complexes was performed using elemental analysis, IR spectroscopy and UV–Vis spectroscopy. The gadolinium complex was further analyzed to determine if DNA is a biological target of this series of metal complexes. In this regard, the interaction between the gadolinium complex and DNA was probed utilizing circular dichroism spectroscopy. The study supports the moderate binding of complex 1 to DNA.
AB - The synthesis and characterization of a family of LnIII complexes (Ln = Gd(1), Tb(2), Dy(3), Ho(4) and Er(5)) of formula [(LnIII(NO3)2(OH2)(pyridoxine)2](NO3) are reported, where pyridoxine is 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine. They were obtained from the reaction of Ln(NO3)3 with pyridoxine in ethanol in a 1:1 M ratio. The crystal structures of representative 1 and 5 were obtained using a single-crystal X-ray diffractometer. The subsequent characterization of all the complexes was performed using elemental analysis, IR spectroscopy and UV–Vis spectroscopy. The gadolinium complex was further analyzed to determine if DNA is a biological target of this series of metal complexes. In this regard, the interaction between the gadolinium complex and DNA was probed utilizing circular dichroism spectroscopy. The study supports the moderate binding of complex 1 to DNA.
KW - Interaction of DNA to metal complex
KW - Lanthanide metal complexes
KW - X-ray
KW - crystallography Pyridoxine
UR - https://digitalcommons.georgiasouthern.edu/chem-facpubs/140
UR - https://reader.elsevier.com/reader/sd/pii/S0020169317303055?token=CC1299CE85DB7817D8625B87432EC36E09A7EDE600A91BC6372C0329EC236BE796DC40EA79F232874199FFA008EBAC20
U2 - 10.1016/j.ica.2017.05.006
DO - 10.1016/j.ica.2017.05.006
M3 - Article
SN - 0020-1693
VL - 464
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
ER -