Synthesis, characterization, computational study, and biological relevance of a family of isostructural, mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) complexes containing pyridoxine, an essential ingredient of vitamin B6 enzyme

Caitlyn E. Stouder; Khairi J. Warren; Olivia F. Perdue; Amanda L. Stewart; Clifford W. Padgett; Allison J. Amonette; Arpita Saha

doi:10.1016/j.ica.2017.05.006

Synthesis, characterization, computational study, and biological relevance of a family of isostructural, mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) complexes containing pyridoxine, an essential ingredient of vitamin B6 enzyme

Caitlyn E. Stouder, Khairi J. Warren, Olivia F. Perdue, Amanda L. Stewart, Clifford W. Padgett, Allison J. Amonette, Arpita Saha

Biochemistry, Chemistry & Physics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The synthesis and characterization of a family of Ln^III complexes (Ln = Gd(1), Tb(2), Dy(3), Ho(4) and Er(5)) of formula [(Ln^III(NO₃)₂(OH₂)(pyridoxine)₂](NO₃) are reported, where pyridoxine is 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine. They were obtained from the reaction of Ln(NO₃)₃ with pyridoxine in ethanol in a 1:1 M ratio. The crystal structures of representative 1 and 5 were obtained using a single-crystal X-ray diffractometer. The subsequent characterization of all the complexes was performed using elemental analysis, IR spectroscopy and UV–Vis spectroscopy. The gadolinium complex was further analyzed to determine if DNA is a biological target of this series of metal complexes. In this regard, the interaction between the gadolinium complex and DNA was probed utilizing circular dichroism spectroscopy. The study supports the moderate binding of complex 1 to DNA.

Original language	English
Pages (from-to)	172-181
Number of pages	10
Journal	Inorganica Chimica Acta
Volume	464
DOIs	https://doi.org/10.1016/j.ica.2017.05.006
State	Published - 2017

Scopus Subject Areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Keywords

Interaction of DNA to metal complex
Lanthanide metal complexes
Pyridoxine
X-ray crystallography

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10.1016/j.ica.2017.05.006

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Stouder, C. E., Warren, K. J., Perdue, O. F., Stewart, A. L., Padgett, C. W., Amonette, A. J., & Saha, A. (2017). Synthesis, characterization, computational study, and biological relevance of a family of isostructural, mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) complexes containing pyridoxine, an essential ingredient of vitamin B6 enzyme. Inorganica Chimica Acta, 464, 172-181. https://doi.org/10.1016/j.ica.2017.05.006

@article{26145a39f2f14c7fbbc1489b0a4cc2d6,

title = "Synthesis, characterization, computational study, and biological relevance of a family of isostructural, mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) complexes containing pyridoxine, an essential ingredient of vitamin B6 enzyme",

abstract = "The synthesis and characterization of a family of LnIII complexes (Ln = Gd(1), Tb(2), Dy(3), Ho(4) and Er(5)) of formula [(LnIII(NO3)2(OH2)(pyridoxine)2](NO3) are reported, where pyridoxine is 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine. They were obtained from the reaction of Ln(NO3)3 with pyridoxine in ethanol in a 1:1 M ratio. The crystal structures of representative 1 and 5 were obtained using a single-crystal X-ray diffractometer. The subsequent characterization of all the complexes was performed using elemental analysis, IR spectroscopy and UV–Vis spectroscopy. The gadolinium complex was further analyzed to determine if DNA is a biological target of this series of metal complexes. In this regard, the interaction between the gadolinium complex and DNA was probed utilizing circular dichroism spectroscopy. The study supports the moderate binding of complex 1 to DNA.",

keywords = "Interaction of DNA to metal complex, Lanthanide metal complexes, Pyridoxine, X-ray crystallography",

author = "Stouder, \{Caitlyn E.\} and Warren, \{Khairi J.\} and Perdue, \{Olivia F.\} and Stewart, \{Amanda L.\} and Padgett, \{Clifford W.\} and Amonette, \{Allison J.\} and Arpita Saha",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

doi = "10.1016/j.ica.2017.05.006",

language = "English",

volume = "464",

pages = "172--181",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier B.V.",

}

Stouder, CE, Warren, KJ, Perdue, OF, Stewart, AL, Padgett, CW , Amonette, AJ & Saha, A 2017, 'Synthesis, characterization, computational study, and biological relevance of a family of isostructural, mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) complexes containing pyridoxine, an essential ingredient of vitamin B6 enzyme', Inorganica Chimica Acta, vol. 464, pp. 172-181. https://doi.org/10.1016/j.ica.2017.05.006

Synthesis, characterization, computational study, and biological relevance of a family of isostructural, mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) complexes containing pyridoxine, an essential ingredient of vitamin B6 enzyme. / Stouder, Caitlyn E.; Warren, Khairi J.; Perdue, Olivia F. et al.
In: Inorganica Chimica Acta, Vol. 464, 2017, p. 172-181.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis, characterization, computational study, and biological relevance of a family of isostructural, mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) complexes containing pyridoxine, an essential ingredient of vitamin B6 enzyme

AU - Stouder, Caitlyn E.

AU - Warren, Khairi J.

AU - Perdue, Olivia F.

AU - Stewart, Amanda L.

AU - Padgett, Clifford W.

AU - Amonette, Allison J.

AU - Saha, Arpita

PY - 2017

Y1 - 2017

N2 - The synthesis and characterization of a family of LnIII complexes (Ln = Gd(1), Tb(2), Dy(3), Ho(4) and Er(5)) of formula [(LnIII(NO3)2(OH2)(pyridoxine)2](NO3) are reported, where pyridoxine is 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine. They were obtained from the reaction of Ln(NO3)3 with pyridoxine in ethanol in a 1:1 M ratio. The crystal structures of representative 1 and 5 were obtained using a single-crystal X-ray diffractometer. The subsequent characterization of all the complexes was performed using elemental analysis, IR spectroscopy and UV–Vis spectroscopy. The gadolinium complex was further analyzed to determine if DNA is a biological target of this series of metal complexes. In this regard, the interaction between the gadolinium complex and DNA was probed utilizing circular dichroism spectroscopy. The study supports the moderate binding of complex 1 to DNA.

AB - The synthesis and characterization of a family of LnIII complexes (Ln = Gd(1), Tb(2), Dy(3), Ho(4) and Er(5)) of formula [(LnIII(NO3)2(OH2)(pyridoxine)2](NO3) are reported, where pyridoxine is 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine. They were obtained from the reaction of Ln(NO3)3 with pyridoxine in ethanol in a 1:1 M ratio. The crystal structures of representative 1 and 5 were obtained using a single-crystal X-ray diffractometer. The subsequent characterization of all the complexes was performed using elemental analysis, IR spectroscopy and UV–Vis spectroscopy. The gadolinium complex was further analyzed to determine if DNA is a biological target of this series of metal complexes. In this regard, the interaction between the gadolinium complex and DNA was probed utilizing circular dichroism spectroscopy. The study supports the moderate binding of complex 1 to DNA.

KW - Interaction of DNA to metal complex

KW - Lanthanide metal complexes

KW - Pyridoxine

KW - X-ray crystallography

UR - https://www.scopus.com/pages/publications/85019576132

U2 - 10.1016/j.ica.2017.05.006

DO - 10.1016/j.ica.2017.05.006

M3 - Article

SN - 0020-1693

VL - 464

SP - 172

EP - 181

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

Stouder CE, Warren KJ, Perdue OF, Stewart AL, Padgett CW , Amonette AJ et al. Synthesis, characterization, computational study, and biological relevance of a family of isostructural, mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) complexes containing pyridoxine, an essential ingredient of vitamin B6 enzyme. Inorganica Chimica Acta. 2017;464:172-181. doi: 10.1016/j.ica.2017.05.006