Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery

Toan Tran, Mariana Hernandez, Dhruvil Patel, Ji Wu

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Electrospun microfibers (MFs) composed of pH and temperature responsive polymers can be used for controllable and variable delivery of ibuprofen. First, electrospinning technique was employed to prepare poly(ε-caprolactone) (PCL) and poly(Nisopropylacrylamide- co-methacrylic acid) (pNIPAM-co-MAA) MFs containing ibuprofen. It was found that drug release rates from PCL MFs cannot be significantly varied by either temperature (22-40°C) or pH values (1.7-7.4). In contrast, the ibuprofen (IP) diffusion rates from pNIPAM-co-MAA MFs were very sensitive to changes in both temperature and pH.The IP release from pNIPAM-co-MAAMFs was highly linear and controllable when the temperature was above the lower critical solution temperature (LCST) of pNIPAM-co-MAA (33°C) and the pHwas lower than the pKa of carboxylic acids (pH 2). At roomtemperature, however, the release rate was dramatically increased by nearly ten times compared to that at higher temperature and lower pH. Such a unique and controllable drug delivery system could be naturally envisioned to find many practical applications in biomedical and pharmaceutical sciences such as programmable transdermal drug delivery.

Original languageAmerican English
JournalAdvances in Materials Science and Engineering
Volume2015
DOIs
StatePublished - Jan 1 2015

Keywords

  • Electrospun microfibers (MFs)
  • Microfibers
  • Variable ibuprofen delivery
  • pH and temperature responsive polymers

DC Disciplines

  • Chemistry

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