The effect of age on theophylline clearance in normal subjects.

W. C. Randolph; John J. Seaman; Brian Dickson; Karl E. Peace; William O. Frank; M. D. Young

doi:10.1111/j.1365-2125.1986.tb02941.x

The effect of age on theophylline clearance in normal subjects.

W. C. Randolph
, John J. Seaman
, Brian Dickson
, Karl E. Peace
, William O. Frank
, M. D. Young

Biostatistics, Epidemiology & Environmental Health Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.

Original language	English
Pages (from-to)	603-605
Number of pages	3
Journal	British Journal of Clinical Pharmacology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2125.1986.tb02941.x
State	Published - Nov 1986

Scopus Subject Areas

Pharmacology
Pharmacology (medical)

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10.1111/j.1365-2125.1986.tb02941.x

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title = "The effect of age on theophylline clearance in normal subjects.",

abstract = " Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31\% of the variability in clearance.",

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AU - Randolph, W. C.

AU - Seaman, John J.

AU - Dickson, Brian

AU - Peace, Karl E.

AU - Frank, William O.

AU - Young, M. D.

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PY - 1986/11

Y1 - 1986/11

N2 - Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.

AB - Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.

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JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

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ER -

The effect of age on theophylline clearance in normal subjects.

Abstract

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