The effect of age on theophylline clearance in normal subjects.

W. C. Randolph; John J. Seaman; Brian Dickson; Karl E. Peace; William O. Frank; M. D. Young

doi:10.1111/j.1365-2125.1986.tb02941.x

The effect of age on theophylline clearance in normal subjects.

W. C. Randolph
, John J. Seaman
, Brian Dickson
, Karl E. Peace
, William O. Frank
, M. D. Young

Biostatistics, Epidemiology & Environmental Health Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.

Original language	English
Pages (from-to)	603-605
Number of pages	3
Journal	British Journal of Clinical Pharmacology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2125.1986.tb02941.x
State	Published - Nov 1986

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Scopus Subject Areas

Pharmacology
Pharmacology (medical)

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10.1111/j.1365-2125.1986.tb02941.x

Cite this

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title = "The effect of age on theophylline clearance in normal subjects.",

abstract = " Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31\% of the variability in clearance.",

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AU - Seaman, John J.

AU - Dickson, Brian

AU - Peace, Karl E.

AU - Frank, William O.

AU - Young, M. D.

N1 - Enter your email address below. If your address has been previously registered, you will receive an email with instructions on how to reset your password. If you don't receive an email, you should register as a new user

PY - 1986/11

Y1 - 1986/11

N2 - Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.

AB - Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.

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ER -

The effect of age on theophylline clearance in normal subjects.

Abstract

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