The Effect of Age on Theophylline Steady-State Serum Levels and Clearance in Normal Subjects

W. C. Randolph; John J. Seaman; Brian Dickson; Karl E. Peace; William O. Frank; M. D. Young

doi:10.1111/j.1365-2125.1986.tb02941.x

The Effect of Age on Theophylline Steady-State Serum Levels and Clearance in Normal Subjects

W. C. Randolph, John J. Seaman, Brian Dickson, Karl E. Peace, William O. Frank, M. D. Young

Biostatistics, Epidemiology, & Environmental Health Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.

Original language	American English
Journal	British Journal of Clinical Pharmacology
Volume	22
DOIs	https://doi.org/10.1111/j.1365-2125.1986.tb02941.x
State	Published - Nov 1986

Keywords

Age
Clearance
Effect
Normal subjects
Steady-state serum levels
Theophylline

DC Disciplines

Biostatistics
Public Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-2125.1986.tb02941.xLicense: Unspecified

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title = "The Effect of Age on Theophylline Steady-State Serum Levels and Clearance in Normal Subjects",

abstract = " Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.",

keywords = "Age, Clearance, Effect, Normal subjects, Steady-state serum levels, Theophylline",

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AU - Randolph, W. C.

AU - Seaman, John J.

AU - Dickson, Brian

AU - Peace, Karl E.

AU - Frank, William O.

AU - Young, M. D.

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PY - 1986/11

Y1 - 1986/11

N2 - Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.

AB - Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.

KW - Age

KW - Clearance

KW - Effect

KW - Normal subjects

KW - Steady-state serum levels

KW - Theophylline

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VL - 22

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

ER -

The Effect of Age on Theophylline Steady-State Serum Levels and Clearance in Normal Subjects

Abstract

Keywords

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