The sorry state of F2 hybrids: Consequences of rapid mitochondrial DNA evolution in allopatric populations

R. S. Burton, C. K. Ellison, J. S. Harrison

Research output: Contribution to journalArticlepeer-review

165 Scopus citations

Abstract

Through the processes of natural selection and genetic drift, allopatric populations diverge genetically and may ultimately become reproductively incompatible. In cases of prezygotic reproductive isolation, candidate systems for speciation genes logically include genes involved in mate or gamete recognition. However, where only postzygotic isolation exists, candidate speciation genes could include any genes that affect hybrid performance. We hypothesize that because mitochondrial genes frequently evolve more rapidly than the nuclear genes with which they interact, interpopulation hybridization might be particularly disruptive to mitochondrial function. Understanding the potential impact of intergenomic (nuclear and mitochondrial) coadaptation on the evolution of allopatric populations of the intertidal copepod Tigriopus californicus has required a broadly integrative research program; here we present the results of experiments spanning the spectrum of biological organization in order to demonstrate the consequences of molecular evolution on physiological performance and organismal fitness. We suggest that disruption of mitochondrial function, known to result in a diverse set of human diseases, may frequently underlie reduced fitness in interpopulation and interspecies hybrids in animals.

Original languageEnglish
Pages (from-to)S14-S24
JournalAmerican Naturalist
Volume168
Issue numberSUPPL.
DOIs
StatePublished - Dec 2006

Scopus Subject Areas

  • Ecology, Evolution, Behavior and Systematics

Keywords

  • Cytonuclear coadaptation
  • Hybrid breakdown
  • Molecular divergence
  • mtDNA

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