Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model

Julia Heimberger; Hannah C. Cade; Jihan Padgett; Vinoth Sittaramane; Abid Shaikh

doi:10.1016/j.bmcl.2015.01.065

Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model

Julia Heimberger, Hannah C. Cade, Jihan Padgett, Vinoth Sittaramane, Abid Shaikh

Biochemistry, Chemistry & Physics

Georgia Southern University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Herbarin A and B were isolated from the fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.

Original language	English
Pages (from-to)	1192-1195
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.bmcl.2015.01.065
State	Published - Mar 15 2015

Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Keywords

Antioxidant properties
Natural products
Total synthesis
Toxicity
Zebrafish

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2015.01.065

Cite this

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title = "Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model",

abstract = "Herbarin A and B were isolated from the fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.",

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author = "Julia Heimberger and Cade, \{Hannah C.\} and Jihan Padgett and Vinoth Sittaramane and Abid Shaikh",

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T1 - Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model

AU - Heimberger, Julia

AU - Cade, Hannah C.

AU - Padgett, Jihan

AU - Sittaramane, Vinoth

AU - Shaikh, Abid

PY - 2015/3/15

Y1 - 2015/3/15

N2 - Herbarin A and B were isolated from the fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.

AB - Herbarin A and B were isolated from the fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.

KW - Antioxidant properties

KW - Natural products

KW - Total synthesis

KW - Toxicity

KW - Zebrafish

UR - https://www.scopus.com/pages/publications/84923774376

U2 - 10.1016/j.bmcl.2015.01.065

DO - 10.1016/j.bmcl.2015.01.065

M3 - Article

C2 - 25690788

AN - SCOPUS:84923774376

SN - 0960-894X

VL - 25

SP - 1192

EP - 1195

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model

Abstract

Scopus Subject Areas

Keywords

UN SDGs

Access to Document

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