Abstract
A simple and efficient synthesis to both enantiomers of highly enantiomerically enriched α-trifluoromethyl-α-(heteroaryl)-glycine derivatives via highly stereoselective aminoalkylation of indoles and pyrroles is described. The triflic acid-catalyzed reaction of enantiomeric 3,3,3- trifluoro-pyruvate-α-methylbenzyl imines with indoles and pyrroles and the subsequent Pd-catalyzed hydrogenolysis of the methylbenzyl group provided the products in high yields and excellent enantioselectivities.
| Original language | English |
|---|---|
| Pages (from-to) | 933-935 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 10 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 6 2008 |
Scopus Subject Areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry